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Latest Kidney Care (Nephropathy) Articles
To see if tightly controlling blood sugar provides improved results in patients who received a kidney transplant, a group of diabetic post-transplant patients were followed for three days. A subset of the randomly assigned group had their blood glucose kept in tight range with IV insulin, while a control group received insulin as they ordinarily would, via injections.
0 comments - Posted Nov 14, 2012
With tens of millions of American facing life with type 2 diabetes and many millions more at risk of the disease, scientists are scrambling to unravel novel treatments. The latest breakthrough could come from California's Salk Institute.
0 comments - Posted May 13, 2012
Erin lay on a bed in the emergency room, finally serious about getting help. Her second episode of diabetic ketoacidosis in a single year had sent her to the hospital shaking and vomiting. For the past seven years, she had been driven by one desire: to lose forty pounds. She refused to give herself her full dose of insulin, fearing weight gain. She hadn't seen her endocrinologist or checked her blood sugar for a year or two.
5 comments - Posted Jul 18, 2011
Need a cheap kidney? How about a quick and easy bypass operation? Medical tourism offers a way for people facing pricey medical procedures to both save money and see another country. And while some, including President Obama, disparage the practice, it's on the rise as healthcare costs in the United States skyrocket beyond the budget of middle-class patients.
4 comments - Posted Jun 17, 2011
If a prisoner on death row wants to donate his organs, should he be allowed to do it?
21 comments - Posted Mar 18, 2011
Tony Flores is a 50-year-old native of El Salvador who works as a construction foreman. He was diagnosed with type 2 diabetes about 12 years ago, after an eye doctor told him it would be a good idea to get his blood sugar checked. He recalls, "I did the test, and they got all freaked out and told me, ‘Oh my god, your A1C is at 12%. You have diabetes type 2. You've got to cut the sugar, you've got to stop drinking orange juice and soda."
2 comments - Posted Mar 15, 2011
It apparently comes as a surprise to many people with type 2 that diabetes can cause kidney disease. In fact, many diabetic patients don't realize that that their condition can cause kidney problems until after they've already developed kidney disease.
0 comments - Posted Feb 24, 2011
Most type 2 meds work by increasing insulin production in one way or another. The extra insulin lowers blood sugar by ushering it out of your bloodstream and into your cells, where it may, unfortunately, make you fat. Wouldn't it be nice if instead, you could lower your high blood sugar by just flushing it right down the toilet?
2 comments - Posted Jan 17, 2011
Data from the massive ACCORD study on intensive blood sugar control shows that lowering blood sugar levels in people with longstanding type 2 diabetes to near-normal may delay the appearance of signs that point to damage to nerves, eyes, and kidneys, but does not stop their progression toward it.
0 comments - Posted Jul 9, 2010
One of the major complications of diabetes is diabetic nephropathy, a loss of kidney function that may lead to renal failure. As kidney disease progresses, the barrier that keeps large molecules out of the urine, called the glomerular barrier, begins to break down. With the barrier failing, certain large molecules begin to migrate into the urine. One of those hefty molecules is immunoglobulin M, or IgM.
1 comment - Posted Aug 19, 2009
The theory of unintended consequences has gotten another boost. Although two drugs designed to slow the loss of kidney function in people with type 1 diabetes turned out to be busts, they had a wonderful but entirely unexpected side effect: Eye damage was reduced by 65 to 70 percent in the patients taking them.
6 comments - Posted Aug 17, 2009
A report commissioned by the U.S. Centers for Disease Control and Prevention (CDC) is being published in this month's issue of the American Journal of Kidney Diseases, the National Kidney Foundation's journal. Led by kidney specialists Dr. Andrew S. Levey at Tufts Medical Center in Boston, Massachusetts, and Dr. William McClellan at Emory University in Atlanta, Georgia, the panel of experts designed a comprehensive public health strategy to prevent the development and complications of chronic kidney disease in the U.S.
1 comment - Posted Mar 19, 2009
In what is believed to be a first-ever procedure, surgeons at Johns Hopkins have successfully removed a healthy donor kidney through a small incision in the back of the donor's vagina.
0 comments - Posted Feb 17, 2009
Utah Jazz owner, Larry H. Miller had his legs amputated six inches below the knee last week. A spokesman for the successful pro basketball team told the Associated Press that the surgery was due to complications from type 2 diabetes. The spokesman noted that Miller was already using a wheelchair before the surgery. Miller is 64 years old.
5 comments - Posted Jan 26, 2009
Researchers at the Chinese University of Hong Kong report that having metabolic syndrome may raise the risk of chronic kidney disease in people with type 2 diabetes.
1 comment - Posted Jan 6, 2009
The day I heard "Diabetes is not the leading cause of heart attack, blindness, kidney disease, and amputation," my life changed. I had believed the opposite to be true for the 32 years I'd been dealing with diabetes. Complications had always hung like a knife over my head.
14 comments - Posted Dec 22, 2008
The first time I presented medical research findings, I was not yet a physician. The year was about 1975. I was in my early forties and a mid-career engineer. The forum was a scientific symposium on diabetes. At the time, I felt that I had discovered the holy grail of diabetes care and was eager to share what I had learned.
22 comments - Posted Dec 8, 2008
Pentoxifylline, a drug used to treat patients with circulation problems, may also benefit those with kidney disease caused by diabetes and other conditions. Specifically, pentoxifylline decreases proteinuria, the abnormal leakage of protein into the urine, according to two articles in the September issue of the American Journal of Kidney Diseases, the official journal of the National Kidney Foundation.
0 comments - Posted Oct 27, 2008
Last week was Kidney Disease Awareness and Education Week. Kidney disease is considered a "quiet disease," and many people don't recognize its early warning signs.
2 comments - Posted Aug 20, 2008
“You need dialysis” are words nobody wants to hear. But today kidney failure doesn’t have to mean driving to and from a clinic three times a week and having a lesser quality of life. Hemodialysis (HD) can safely be done in the privacy of your home in two new ways: daily and nocturnal home HD, both of which can help you feel better and live longer.
6 comments - Posted Mar 19, 2008
A1c tests, the standard measurement of blood glucose, underestimate the amount of glucose in people who are on kidney hemodialysis, says a Wake Forest University Baptist Medical Center study.
2 comments - Posted Feb 27, 2008
Because scientists often tend to dismiss what they don't fully understand, many of them used to think that C-peptide had no physiological function. But while it's true that C-peptide does nothing to lower blood sugar, recent research is finding that it might have a role in preventing diabetes complications.
19 comments - Posted Jan 3, 2008
Today's Wall Street Journal article on kidney donations highlights a topic that can be important to people with diabetes. Many people on donor recipient lists have diabetes. (Currently 75,000 people in the United States are awaiting organ transplants.)
0 comments - Posted Dec 15, 2007
Everyone knows that elevated sugar levels and long-time type 1 diabetes are risk factors for kidney disease. But now researchers have learned that high blood pressure, high lipid levels, and male gender are also risk factors for renal failure.
1 comment - Posted Dec 10, 2007
March 13, 2008, heralds the third annual World Kidney Day - an event that will be celebrated in more than 60 countries. We take this opportunity to recount how this concept has gained worldwide traction and momentum and to reflect on the challenges faced by its creators and supporters.
1 comment - Posted Oct 29, 2007
Dialysis is a subject cloaked in alarming myths and misconceptions. The public mind tends to envision dialysis patients as huddled in seedy clinics, hooked up to machines like iron lungs and knocking weakly at death's door.
1 comment - Posted Sep 8, 2007
A new study of the much-studied Pima Indian tribe has identified a set of urine proteins that predicts who will get diabetic nephropathy ten years down the line.
0 comments - Posted May 7, 2007
Q: Are there any long-term side effects of the popular drugs to treat type 2 diabetes?
2 comments - Posted Mar 24, 2007
BRUSSELS - 1 February 2007. Globally more than 500 million individuals, or about one adult in ten, have some form of chronic kidney disease (CKD). Approximately 1.5 million people must be kept alive with dialysis, and wait up to seven years for a transplant - if one is available.
0 comments - Posted Feb 28, 2007
For type 2s who suffer from kidney disease, treatment with ruboxistaurin was shown to reduce albuminuria and maintain estimated glomerular filtration rate (eGFR) for more than one year. Ruboxistaurin—a PKC inhibitor manufactured by Eli Lilly and Company—may have added benefit in established therapies for diabetic kidney disease.
0 comments - Posted Apr 1, 2006
Hong Kong researchers say that if you have type 2 and suffer from kidney disease, you may be better off getting structured care from a pharmacist-diabetes specialist team.
0 comments - Posted Apr 1, 2006
Italian researchers say that kidney disease is a “significant predictor” of death, and that people who have kidney problems at the time of their diabetes diagnosis should be treated aggressively from the onset.
0 comments - Posted Apr 1, 2006
Diabetes duration and A1C remain the gold standard for determining whether you may develop retinopathy and neuropathy. However, if you are a type 1 with a weight problem, you may not be slowing down the progression to these microvascular complications.
0 comments - Posted Sep 1, 2005
Although the complications of diabetes are well known, scientists don’t fully understand the mechanisms that underlie them. However, a key to the mystery lies in what are known as advanced glycosylation end-products (AGEs).
0 comments - Posted Jul 1, 2005
Diabetes is one of the leading causes of kidney failure, which soaks up a large part of the national health care dollar. However, kidney disease is preventable and treatable once present.
0 comments - Posted Jun 1, 2005
In November 2004, the International Society of Nephrology (ISN) asked national health bodies around the world to consider the urgent implementation of proactive albumin (protein) screening in urine.
0 comments - Posted Feb 1, 2005
Annual screening for microalbuminuria (low levels of protein in the urine, indicating early signs of kidney disease) in type 1 diabetes should begin with puberty and/or after five-year disease duration of diabetes.
0 comments - Posted Oct 1, 2004
Swedish researchers say that smoking is associated with both poor blood glucose control and microalbuminuria (protein in the urine) that indicates early kidney disease and increased heart disease risk.
0 comments - Posted Oct 1, 2004
Annual screening for microalbuminuria (low levels of protein in the urine, indicating early signs of kidney disease) in type 1 diabetes should begin with puberty and/or after five-year disease duration of diabetes.
0 comments - Posted Oct 1, 2004
The risk of cardiovascular events and death in people with diabetes and high blood pressure is two to eight times higher when microalbuminuria is present.
0 comments - Posted Jun 1, 2004
Kidney School is a new, free interactive learning resource on the Web. It offers educational materials designed to teach kidney patients about kidney disease, treatment options and day-to-day coping skills.
0 comments - Posted Apr 1, 2003
A new study has examined the relationship of decreased heart rate variability—the beat-to-beat alterations in heart rate—to protein in the urine and observable kidney disease. The study reports that severely reduced heart rate variability at baseline was associated with progressive kidney deterioration one year later.
0 comments - Posted Apr 1, 2003
Pima Indians who developed type 2 diabetes before they were 20 years old later developed kidney disease at the same rate as those who got type 2 as adults.
0 comments - Posted Apr 1, 2003
A recent study comparing three classes of blood pressure medications found that an ACE inhibitor did the best job of slowing kidney disease in African-Americans.
0 comments - Posted Mar 1, 2003
An average of 2,500 premature deaths per year occur in for-profit kidney dialysis centers in the United States, according to research that analyzed data from eight large observational studies covering the years 1973 through 1997 and including more than 500,000 patient-years of data.
0 comments - Posted Feb 1, 2003
If you're an African-American with diabetes and kidney disease, chances are good that your brother or sister might have kidney disease, too.
0 comments - Posted Feb 1, 2003
When a "planned care" system of healthcare delivery was instituted in three primary-care practices in Wisconsin and Minnesota, it resulted in better care by physicians and in better diabetes control for their patients, according to researchers from the Mayo Health System Diabetes Translation Project.
0 comments - Posted Feb 1, 2003
A test that measures muscle activity can predict the development of foot ulcers, while other tests can predict amputation and even death, say researchers at the Manchester Royal Infirmary in the United Kingdom.
0 comments - Posted Jan 1, 2003
Renal (kidney) function declines more rapidly in people with type 2 diabetes who have both retinopathy and proteinuria (protein in the urine).
0 comments - Posted Jan 1, 2003
Irbesartan (Avapro), an angiotensin II receptor blocker (ARB), reduces 24-hour systolic and diastolic blood pressure as well as albumin excretion rate (AER) in people with type 2 diabetes.
0 comments - Posted Jan 1, 2003
When people with type 1 or type 2 diabetes donate a kidney, the rejection rate is no different than in cases in which the donor does not have diabetes. However, the recipients of kidneys from type 1 or 2 donors have a greater incidence of proteinuria—an excessive amount of protein in the urine, a sign of kidney disease—and are more likely to have elevated blood-glucose levels requiring treatment after the transplant.
0 comments - Posted Dec 1, 2002
A five-year study measuring overnight blood pressure in 75 adolescents and young adults with type 1 diabetes revealed that high nighttime blood pressure can lead to kidney disease.
0 comments - Posted Dec 1, 2002
A five-year study measuring overnight blood pressure in 75 adolescents and young adults with type 1 diabetes revealed that high nighttime blood pressure can lead to kidney disease.
0 comments - Posted Dec 1, 2002
Cutting your carbs and increasing your protein intake? You could be damaging your kidneys, according to researchers who studied the effects of a low-carbohydrate, high-protein diet on 10 people who did not have diabetes.
0 comments - Posted Nov 1, 2002
Should you skip eating animal protein in favor of vegetable protein if you have type 2 diabetes and microalbuminuria (a sign of kidney disease)?
0 comments - Posted Oct 1, 2002
1) Control Your Blood Pressure
0 comments - Posted Sep 1, 2002
Everyone needs to start giving kidney dysfunction and cardiovascular disease equal standing as complications in diabetes mellitus.
0 comments - Posted Sep 1, 2002
Unless you are undergoing kidney dialysis or have congestive heart failure, having diabetes puts you at no more risk of having a heart attack or dying following major surgery on blood vessels than people without diabetes, researchers say.
0 comments - Posted Aug 1, 2002
The Juvenile Diabetes Research Foundation International (JDRF) is seeking participants for a study on the role that genes play in the development of diabetic kidney disease in people with type 1 diabetes. Entitled the "Genetics of Kidneys in Diabetes (GoKindD) Study," it requires participants and their parents to submit blood and urine samples and medical histories.
0 comments - Posted Apr 1, 2002
People with end-stage kidney disease who receive dialysis in the morning may survive longer than those who receive the same treatment at other times of the day, according to researchers from Emory University.
0 comments - Posted Apr 1, 2002
Q: Are pancreas transplants very successful for someone who has had a previous successful kidney transplant? I have been considering a pancreas transplant, but several doctors have told me the success rates are not that good and that, in some cases, the individual develops a milder form of diabetes.
0 comments - Posted Mar 1, 2002
If you have type 1 diabetes with an A1C greater than 8% and you are also a smoker, you are at higher risk for microalbuminuria—abnormal levels of protein in the urine that signal kidney complications—warn researchers at the Joslin Diabetes Center.
0 comments - Posted Mar 1, 2002
Short-term treatment with vitamins C and E lowers the urinary albumin excretion rate (AER) in people with type 2 diabetes who have micro/macroalbuminuria, according to a team of Danish researchers. In the September 2001 issue of Diabetic Medicine, they suggest that further long-term, large-scale studies of this albuminuria-reducing treatment modality are needed.
0 comments - Posted Jan 1, 2002
Nearly one-quarter of research subjects with type 1 diabetes who had diabetic kidney disease showed signs of remission of their kidney disorder after beginning treatment with angiotensin-converter enzyme (ACE) inhibitors, say researchers at the Steno Diabetes Center in Gentofte, Denmark.
0 comments - Posted Jan 1, 2002
The National Kidney Foundation has issued a dining guide that will help people with kidney problems maneuver their way through restaurant menus and make healthy eating choices.
0 comments - Posted Dec 1, 2001
Taking Cozaar (losartan potassium) may prevent the progression of kidney disease, say researchers at Harvard. The drug, FDA-approved to treat high blood pressure and hypertension, was shown to lower the risk of kidney disease and end-stage renal disease (ESRD) in people with type 2 diabetes. Results of the study were published in the September 20 issue of The New England Journal of Medicine.
0 comments - Posted Dec 1, 2001
Researchers in the United Kingdom say that the anti-rejection medication sirolimus (Rapamune) allows for the early withdrawal of the anti-rejection drug cyclosporine in people who have had a kidney transplant.
0 comments - Posted Nov 1, 2001
Australian researchers are saying the angiotensin-converting enzyme (ACE) inhibitor perindopril (Aceon) is more effective than the calcium channel blocker nifedipine (Procardia) in slowing the progression of kidney disease in people with diabetes who have normal blood pressure.
0 comments - Posted Sep 1, 2001
After four years on dialysis, with no sign that he was nearing the top of the transplant waiting list, Moshe Tati decided to buy a kidney. This was easier than he had imagined. Several months previous, the name and telephone number of an organ broker had been passed, furtively, around his dialysis group. At the time, Moshe did not think he would use the telephone number. He thought he would wait.
1 comment - Posted Aug 1, 2001
Don't look for rising blood pressure as a first indicator of impending kidney disease if the subject is a child.
0 comments - Posted Jul 1, 2001
According to researchers in Sweden, eating fish protein reduces the risk of developing microalbuminuria, a condition marked by protein in the urine that is associated with kidney disease.
0 comments - Posted Jul 1, 2001
Marilyn never expected that a routine heart exam would cause kidney damage. But it did.
1 comment - Posted Apr 1, 2001
Diabetes is the most common single cause of end-stage renal disease (ESRD) in the United States and Europe. In the United States, diabetic nephropathy (kidney disease) accounts for about one-third of all cases of ESRD. Most patients with ESRD usually go on dialysis or require a kidney transplant to survive.
0 comments - Posted Apr 1, 2001
To prevent or slow progression to end-stage renal disease, Robert Stanton, MD, chief of nephrology at Joslin Diabetes Center in Boston recommends taking the following steps:
0 comments - Posted Apr 1, 2001
Can you tell if little Susie or Johnny is likely to experience diabetes-related kidney problems in later years? Even if the diagnosis of type 1 diabetes is fairly new?
0 comments - Posted Mar 1, 2001
A healthy dose of vitamins may be a valuable tool in lowering urinary albumin excretion rates in people with type 2 diabetes. Unveiled at this year's August meeting of the European Association for the Study of Diabetes, a recent Danish study found that taking large daily doses of vitamins C and E significantly reduced short-term levels of albumin excretion in the urine (Diabetologia, Vol. 43, Suppl. 1, p. A36).
1 comment - Posted Feb 1, 2001
Beef may be what's for dinner, but eating a mostly chicken diet can greatly reduce one's chances of developing kidney disease.
0 comments - Posted Aug 1, 2000
Quintessence, a proprietary formulation of essential amino acids, may be used to supplement protein needs for patients with kidney failure who require a low-protein diet. In addition, Quintessence, manufactured by Calwood Nutritionals of Baltimore, can be used to enhance nutritional status in people with a normal protein intake.
0 comments - Posted Jun 1, 2000
Jane Botcha has had diabetes for over six years. When she was tested in 1996, her microalbuminuria was 2.4. In 1997 it rose to 7.4, and this year it was 17.1.
0 comments - Posted Jan 1, 2000
Researchers at the Joslin Diabetes Center in Boston have launched the Joslin Kidney Study to search for genetic components that make some people with type 1 diabetes prone to kidney complications.
0 comments - Posted Nov 1, 1999
Kidney transplant patients who suffered high blood sugar when taking the antirejection drug tacrolimus (Prograf) demonstrated improvement when they were switched to the antirejection drug cyclosporin (Neoral).
1 comment - Posted Jul 1, 1999
The jury has been out on whether people who are at risk for diabetic kidney disease but have normal blood pressure should use angiotenisin converting enzyme (ACE) inhibitors. Traditionally, ACE inhibitors have been used to treat people with hypertension, but lately, they have become a mainstream treatment option of diabetic kidney disease.
0 comments - Posted Mar 1, 1999
As early as this summer, the National Institutes of Health (NIH) will begin recruiting candidates with type 1 diabetes for a new islet and kidney transplant study.
0 comments - Posted Mar 1, 1999
Current evidence suggests that lipoproteins (such as LDL-cholesterol) need to be oxidized to cause atherosclerosis. Such oxidative stress appears to be increased in diabetes, which causes additional atherosclerosis.
0 comments - Posted Dec 1, 1998
Bayer Inc. has developed a new test which simplifies screenings for kidney disease, and could potentially save the lives of many people with diabetes. Kidney disease leads to other illnesses and dependence on kidney dialysis.
0 comments - Posted Oct 1, 1998
In addition to the host of health risks that smoking presents to all people, studies have shown that adult type 1 smokers are at increased risk to develop macrovascular and microvascular diabetic complications, especially retinopathy and nephropathy. A recent study from Germany shows that markers of microvascular complications are also found in teen smokers with type 1 diabetes.
0 comments - Posted Jul 1, 1998
If you have type 1 diabetes, check your family history. Patients with type 1 diabetes whose parents had high blood pressure (hypertension) showed a greater incidence of diabetic nephropathy compared to patients whose parents did not, according to a study published in the March issue of Diabetes. Study authors Johan A. Fagerudd, et al. also reports that patients with type 1 diabetes have a greater chance of developing hypertension, and at a younger age, if their parents had hypertension.
0 comments - Posted Apr 1, 1998
The Philadelphia-based Exocell, Inc. has recently signed an agreement with Eurand International for the clinical development of an orally administered compound that could help prevent diabetic kidney disease. The compound, EXO-226, will be produced and supplied by Eurand for use in the first phase of clinical trials for FDA approval. Exocell anticipates that these trials will begin in early 1997.
0 comments - Posted Jan 1, 1997
A study published in the December 1995 issue of Lancet, indicating a dual pancreas-kidney transplant may be more dangerous than previously suspected, has stirred controversy at the University of Minnesota.
0 comments - Posted Jul 1, 1996
Diabetes-induced nephropathy is now the leading cause of end-stage renal failure in New Zealand, according to the Department of Medicine at Auckland Hospital in New Zealand.
0 comments - Posted Mar 1, 1995
Though it may be a promising alternative for many people with type 2 diabetes, the drug metformin may cause severe side effects, even death, in some patients.
0 comments - Posted Mar 1, 1995
A study was conducted by the School of Medicine in Baltimore, Maryland to determine the proportion of end-stage renal failure in people with diabetes.
0 comments - Posted Jan 1, 1995
The largest and longest study ever conducted to learn about the effects of a medication on people with nephropathy recently concluded. It found that a drug called Captopril can slow or halt the progression of nephropathy (kidney disease) in people with diabetes who show signs of this complication. Captopril is an ACE inhibitor, a medication used to treat hypertension.
0 comments - Posted May 1, 1994
According to a report from the University Hospital in Linkoping, Sweden, the incidence of nephropathy has decreased dramatically. The report is based on a study of 213 people with type I diabetes, who had been diagnosed before the age of 15 between 1961 and 1980.
0 comments - Posted Mar 1, 1994
Researchers at Heinrich-Heine University in Dusseldorf, Germany have linked smoking with the progression of diabetic nephropathy in people with type 1 diabetes undergoing hypertension therapy. The study was conducted over one year and included 34 smokers, 24 ex-smokers (anyone who had quit prior to the study), and 35 non-smokers, all of whom had both retinopathy and nephropathy (to insure that diabetes was the cause).
0 comments - Posted Mar 1, 1994
For the last ten years the DCCT has been a big part of the participants' lives, affecting everything from what they eat to how they control their diabetes. The study is over now; the doctors have proven the effectiveness of intensive therapy, they have told us that tight control is the new standard in diabetes care. But they have not told us what the new therapies are like and how they affect our day to day life. For that we must talk to the participants themselves. We contacted eleven of the patients for their insights on the study and the therapies they used.
0 comments - Posted Jul 1, 1993
Improved blood sugar control, smoking cessation and aggressive blood pressure treatment are mainstays for preventing or treating the development of kidney disease in people with diabetes. Increasingly, physicians are also turning to a class of drugs called ACE inhibitors to slow the progression of kidney disease in their patients.
1 comment - Posted Jan 1, 1991