Taiwanese researchers say that a technology that uses sound waves to stimulate healing in diabetic foot ulcers is almost three times more effective than conventional hyperbaric oxygen therapy (HBOT). The technology, called dermaPACE®, is manufactured by SANUWAVE Health Inc., a medical device company located in Alpharetta, Ga.
Results are expected by the end of the month in an efficacy study on a new drug that promises to improve diabetic wound care. Derma Sciences is wrapping up work on a phase 2 trial of DSC127, a drug already shown to speed up healing in animal tests.
It sounds like science fiction: a substitute for human skin, derived from human cells and used to treat difficult-to-treat diabetic foot ulcers. But it's a real product, called Dermagraft, manufactured and sold by a real company, Advanced BioHealing. The Connecticut-headquartered company is expanding its operations in Tennessee, part of an aggressive growth strategy to spread the word about its existing product and develop new ones.
Epic Wound Care, a subsidiary of New York-based United EcoEnergy Corp., has signed a three-year sponsorship agreement with the American Diabetes Association in support of the ADA's "Mission to Stop Diabetes®" campaign.
Researchers at Loyola University have discovered a group of immune system cells called natural killer T (NKT) cells that slow the wound healing process. Their findings pave the way for potential new treatments to accelerate the healing process in slow-to-heal wounds that can occur in people with autoimmune disorders such as type 1 diabetes.
Deferoxamine, a drug already FDA-approved for the treatment of disorders related to excess iron in the blood, may help doctors heal stubborn leg and foot wounds in people with diabetes. Scientists at the Stanford University School of Medicine and the Albert Einstein College of Medicine found that with deferoxamine, small cuts in diabetic mice healed 10 days faster than they did in untreated mice: 13 days as opposed to 23 days. If deferoxamine works similarly on humans, it could significantly speed the healing of diabetic wounds.
A 43-year-old Iraq war veteran with diabetes is living in Texas with his wife and four young children when he is told that he must prepare for the amputation of one of his legs. The spreading, non-healing wounds and their complications make the amputation necessary to save not just his limb, but his life, his doctors tell him. But he refuses to proceed with the amputation surgery.
The incidence of limb-threatening ulcerations in diabetics is very high, affecting approximately one in six to seven patients. Non-healing "diabetic" ulcers are the major cause of leg, foot, and toe amputations in this country, after traumatic injuries such as motor vehicle accidents. These ulcerations do not occur spontaneously; they are always preceded by gradual or sudden injury to the skin by some external factor. Preventing such injuries can prevent their sad consequences.
The newly opened Center for Wound Care and Hyperbaric Medicine in Stoughton, Mass., is now offering comprehensive wound management care, including hyperbaric oxygen therapy (HBOT), which has been used successfully to treat diabetic ulcers.
The use of honey as a healing salve was recently the subject of a review of
eighteen studies covering over sixty years. According to the study author, Dr.
Fasal Raul Khan, honey was the bee's knees for wound healing throughout ancient
history - it was even found in the tomb of King Tutankhamun, still edible after
all those years.
MINNEAPOLIS/ST. PAUL, June 19, 2007 - Birgitta I. Rice, MS, RPh, CHES, University of Minnesota School of Public Health, has developed a therapy that is proven to relieve leg pain and improve healing of chronic foot ulcers in patients with diabetes or peripheral arterial disease. The training protocol was published in the May/June issue of The Diabetes Educator.
In days of yore, along about the time when bloodletting was
considered a legitimate cure, maggots were a popular tool in the
surgeon's black bag. In the Civil War, doctors employed busy
maggots to clean rotten tissue from wounds that might otherwise have
led to amputation.
The U.S. National Institutes of Health recently awarded a $1 million grant to a research team in Scotland to begin clinical trials of a new method to treat nonhealing wounds such as diabetic ulcers and pressure sores, according to a release from the University of Dundee.
"Maggot debridement is a valuable and rational treatment option for many ambulatory, home-bound and extended-care patients who have non-healing wounds," say researchers from the University of California, Irvine in the September issue of Archives of Physical Medicine and Rehabilitation.
Electric pulses helped to heal foot ulcers for people with diabetes, according to the results of a study out of the University of Texas that were published in the June issue of the Archives of Physical Medicine and Rehabilitation.
Podiatrists argue that moist-wound healing is of utmost importance for diabetic foot wounds to properly heal. According to Debashish Chakravarthy, PhD, head of consumer business development for Advanced Medical Solutions, a new bandage, called the Spyroflex, is specially designed to provide this type of healing environment.
Only a month and 12 days after receiving recommendation for approval from a FDA advisory board, Apligraf was formally given approval for the treatment of diabetic foot ulcers of greater than a three-week duration.
Dermagraft, a human skin replacement for the treatment of diabetic foot ulcers has been recommended to the FDA for approval on the condition that Advanced Tissue Sciences, Inc. and its partner Smith & Nephew plc perform a post marketing study.
An estimated 1.2 million people with diabetes suffer from lower extremity ulcers each year, and of all the foot amputations in the United States, 84 percent, or 60,000 amputations, are related to diabetic foot ulcers.
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