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Islet & Pancreas Transplant Archives

Islet & Pancreas Transplant Article Archives

May 2011

N.J. Hospital Teams With Ricordi to Find Cure for Type 1

New Jersey's Hackensack University Medical Center has announced that it will partner with Dr. Camillo Ricordi to test a surgical procedure that could hold the key to a cure for type 1 diabetes.

comments 10 comments - Posted May 18, 2011

Moms of Children with Diabetes Tell Their Stories, Ask to Support Research For a Cure

HOLLYWOOD, FL -- They come from New York, Miami, Milwaukee and more. They have children of all ages with type 1 diabetes - and they're on a mission to find a cure. They're the "Real Moms of the DRI Foundation" and in honor of Mother's Day they're asking millions of moms - and others - to support the Diabetes Research Institute, a world leader in cure-focused research.

comments 2 comments - Posted May 8, 2011

March 2011

Pre-Diabetes Glossary

This List defines terms that people with prediabetes commonly encounter as they learn more about the condition.

comments 2 comments - Posted Mar 29, 2011

Should States Let Inmates Donate Organs?

If a prisoner on death row wants to donate his organs, should he be allowed to do it?

comments 19 comments - Posted Mar 18, 2011

December 2010

Stem cells used to make pancreas, gut cells

(Reuters) - Stem cells can be transformed into the pancreatic cells needed to treat diabetes and into complex layers of intestinal tissue, scientists demonstrated in two experiments reported on Sunday.

comments 6 comments - Posted Dec 13, 2010

June 2010

Double Transplantation Treatment for Type 1 Diabetes

City of Hope researchers have found that bone marrow transplantation with islet cell transplantation shows promise as a treatment for late-stage type 1 diabetes. This combination may enable patients to make their own insulin again.  Results from laboratory research led by Defu Zeng, MD, associate professor in the departments of Diabetes Research and Hematology & Hematopoietic Cell Transplantation at City of Hope, were published online this month in the journal Diabetes.

comments 0 comments - Posted Jun 25, 2010

Academia, Biotech and the Pharmaceutical Industry Have Joined Forces to Fight Diabetes

IMIDIA ("Innovative Medicines Initiative for Diabetes"), a public private consortium funded by the Innovative Medicines Initiative (IMI), announced today the launch of a project focusing on pancreatic islet cell function and survival. Academia, biotech and pharma industry have joined forces to develop biomarkers and tools to pave the way for improved disease management and ultimately provide a cure for diabetes.

comments 0 comments - Posted Jun 18, 2010

April 2010

Insulin-Producing Cells Derived from Specially Bred Pigs

NEW YORK, April 27, 2010 - The Juvenile Diabetes Research Foundation announced today that it is partnering with Living Cell Technologies (LCT), a New Zealand-based biotechnology company focused on developing cell based therapeutics, in a Phase II clinical trial to study the safety and effectiveness of transplanting encapsulated insulin-producing cells from pigs as a treatment for type 1 diabetes with significant hypoglycemia unawareness.

comments 1 comment - Posted Apr 28, 2010

February 2010

Researchers Discover Protein that Triggers Islet Cell Rejection

Researchers at RIKEN and Fukuoka University have pinpointed the mechanism responsible for early rejection of transplanted pancreatic islet cells in the treatment of type 1 diabetes. A new system based on this mechanism has been shown to vastly increase transplant efficiency, setting the stage for the development of powerful new treatment techniques.

comments 5 comments - Posted Feb 9, 2010

January 2010

Skin cells transformed directly into nerve cells: Are beta cells next?

WASHINGTON (Reuters) - Researchers have transformed ordinary mouse skin cells directly into neurons, bypassing the need for stem cells or even stemlike cells and greatly speeding up the field of regenerative medicine.

comments 0 comments - Posted Jan 29, 2010

Pancreas Transplant Program Opens at Montefiore Medical Center

NEW YORK, Jan. 14 /PRNewswire-USNewswire/ -- Montefiore Medical Center continues to expand its portfolio of options for patients in need of organ transplantation. The new Pancreas Transplant Program will treat patients with severe, end-stage diabetes. As the only Pancreas Transplant Program in the Bronx and Westchester, and one of only several in Greater New York, patients will be able to receive world-class care close to home. The program currently has nine patients medically approved and waiting for a pancreas transplant.

comments 2 comments - Posted Jan 16, 2010

ProtoKinetix Anti-Aging Glycopeptides Show Promise Against Diabetes

One potential avenue for the treatment for type 1 diabetes is to transplant insulin-producing islet cells into the body. The Edmonton Protocol is a method of implanting pancreatic islets into the liver for the treatment of type 1 diabetes. The protocol is named for the islet transplantation group at the University of Alberta in Edmonton, Canada, where the protocol was first devised in the late 1990s.

comments 3 comments - Posted Jan 13, 2010

December 2009

Airman Injured in Afghanistan Receives Unprecedented Islet Cell Transplant

WASHINGTON, Dec. 15 /PRNewswire-USNewswire/ -- A 21-year old Airman severely wounded in Afghanistan is recovering at Walter Reed Army Medical Center after several surgeries and an unprecedented transplant.

comments 2 comments - Posted Dec 17, 2009

IBsolvMIR®, a Drug That Prevents Islet Transplantation Rejection, Receives FDA -Orphan Drug- Status

A Swedish biotechnology company, TikoMed AB, has received notice that the U.S. Food and Drug Administration is granting orphan drug designation to its IBsolvMIR® drug for preventing the rejection of transplanted pancreatic islet cells in type 1 patients.

comments 0 comments - Posted Dec 4, 2009

November 2009

Pancreatic Islet Autoantibodies as Predictors of Type 1 Diabetes

Many autoimmune diseases, such as lupus erythematosis and type 1 diabetes, are caused by autoantibodies. An autoantibody is an antibody (a protein) produced by the immune system of an individual, which is directed against a different protein of the the same individual.

comments 4 comments - Posted Nov 30, 2009

September 2009

Promising Pancreate Creates New Islets

One thing that really frustrates people with diabetes mellitus is the biopharma industry's focus on treatments rather than cures. A cure is what the diabetes community wants, not another band-aid. So the existence of a biopharma company that calls itself "CureDM" is promising, and its first product, Pancreate, seems to be on its way to fulfilling that promise.

comments 21 comments - Posted Sep 28, 2009

July 2009

Islet Transplant Recipient Shares Her Experiences with the Edmonton Protocol

April 2009 was an exciting month at the University of Alberta. It marked the tenth anniversary of an unprecedented approach to islet transplantation, recognized globally as the "Edmonton Protocol." Each year since that milestone has produced evidence of progress in the art of islet isolation and the science of the transplant process. I know this because I lived it. I am patient number thirty-three, one of the many who have witnessed the evolution of this continuing innovation.

comments 7 comments - Posted Jul 11, 2009

January 2009

Chicago Diabetes Project Collaborates Globally to Find the Cure

Nearly every time that I mention islet transplantation in a conversation about diabetes, the person I'm with responds with a sniff that it's never going to work because of the immune suppression problem.

comments 12 comments - Posted Jan 23, 2009

December 2008

Has Anyone Else Reversed Diabetes Complications? If You Have, I Want to Hear From You!
Has Anyone Else Reversed Diabetes Complications? If You Have, I Want to Hear From You!

Are you a scientific anomaly like me?  Have you or someone you know reversed the complications associated with diabetes? Did you suffer microvascular and macrovascular damage during the “growing pains” of coming to terms with having no choice but to live your life with diabetes? Then, did you turn around and find love and hope, which made you change your life? And after changing it, did you find after several years that you were healing the damage that you had incurred by your own misguided hand? 

comments 117 comments - Posted Dec 25, 2008

Non-Beta Pancreatic Cells Can Be Stimulated to Become New Beta Cells
Non-Beta Pancreatic Cells Can Be Stimulated to Become New Beta Cells

Non-beta "progenitor" cells in the pancreas can be stimulated to turn into beta cells even after birth or autoimmune injury to the pancreas, say researchers at Joslin Diabetes Center in Boston, an affiliate of Harvard Medical School.

comments 3 comments - Posted Dec 2, 2008

Who Are Those Masked Cells? They’re Researchers’ Answer to Avoiding Transplant Rejection
Who Are Those Masked Cells? They’re Researchers’ Answer to Avoiding Transplant Rejection

One of the most promising approaches to the treatment of type 1 diabetes is the transplantation of human islet cells. The major drawback to the procedure has been that even though recipients initially enjoy revitalized pancreases that pump out copious amounts of insulin, their immune systems soon act as spoilsports and reject the donated cells. 

comments 0 comments - Posted Dec 2, 2008

November 2008

Research Centers Report “Encouraging Results” in Tests of Artificial Pancreases
Research Centers Report “Encouraging Results” in Tests of Artificial Pancreases

Even as diabetes researchers worldwide strive for total control over-or even an outright cure of-type 1 diabetes via gene therapy, altered cells, or surgical intervention, other researchers continue to press toward creation of a functional "artificial pancreas."

comments 1 comment - Posted Nov 3, 2008

October 2008

Grandmother Armed With New Pancreas
Grandmother Armed With New Pancreas

A 55-year-old woman whose pancreas was removed due to chronic pancreatitis is not without a pancreas, thanks to the ingenuity of surgeons at the Methodist Hospital in Houston. After they removed her pancreas, they extracted its islet cells and implanted them into her left forearm, creating what they call a functioning pancreas in her arm. (Transplanted islet cells are usually injected into the liver, but in this case the patient's liver had damage that precluded its use.) Apparently the patient is recovering handily and should be armed with insulin as soon as the transplanted cells become fully functional.

comments 3 comments - Posted Oct 20, 2008

It’s a Boy!  It’s a Girl!  It’s a Medical Grade Piglet!
It’s a Boy! It’s a Girl! It’s a Medical Grade Piglet!

Back in 2007, a gleaming porker barn, unlike anything ever before seen in the annals of pigsty architecture, began operations in western Wisconsin. Known as the Diabetes Research and Wellness Foundation Islet Resource Facility, the barn is operated by the Spring Point Project. The Project's ultimate goal is to provide an unlimited supply of high-grade pig pancreatic islets for transplant into people with diabetes.

comments 3 comments - Posted Oct 20, 2008

July 2008

NIH Funds Research in Four Countries to Improve Islet Transplantation
NIH Funds Research in Four Countries to Improve Islet Transplantation

The National Institutes of Health will fund studies at 11 research centers in the United States, Canada, Sweden and Norway to look into ways to improve outcomes and lessen the side effects from islet cell transplantations in people with type 1 diabetes.

comments 1 comment - Posted Jul 17, 2008

March 2008

Can a Tuberculosis Vaccine Reverse Type 1? Phase 1 Trial Now Underway Seeks Answer

Scientists at Massachusetts General Hospital (MGH) in Boston have initiated a phase 1 clinical trial to reverse type 1 diabetes.  The trial is exploring whether the promising results from the laboratory of Denise Faustman, MD, PhD, can be applied in human diabetes.

comments 13 comments - Posted Mar 19, 2008

The Cure: The Slow Road to Hope

Talk of a cure has been around forever. Sometimes it seems as if the cure is a constantly receding dream, always ten years away or just around the next corner.

comments 12 comments - Posted Mar 9, 2008

February 2008

Scientists Report Advances Against Diabetes at Levine Symposium in Southern California

City of Hope researchers were among the more than 50 international investigators reporting advances against type 1 diabetes at the recent Rachmiel Levine Diabetes and Obesity Symposium in Newport Beach, Calif.

comments 4 comments - Posted Feb 9, 2008

January 2008

Sponsor a Pig Now, Help Insulin Cell Transplants Later
Sponsor a Pig Now, Help Insulin Cell Transplants Later

Sponsor a pig and you can help a unique collaboration between Spring Point Project and the University of Minnesota to begin transplanting insulin-producing islet cells from pigs to humans within the next two years.

comments 10 comments - Posted Jan 24, 2008

December 2007

Pig Pancreas Cells Seem to Thrive in Diabetic Monkeys

Awhile back, three macaque monkeys with type 1 diabetes received transplants of 19 pig pancreas primordia, each one smaller than the period at the end of this sentence.

comments 5 comments - Posted Dec 31, 2007

November 2007

The Hip Bone's Connected to the

First we find out that our belly fat is an endocrine organ, and now it's our bones. Dr. Gerard Karsenty of Columbia University has discovered that bone-building cells (osteoblasts) secrete a hormone called osteocalcin that not only tells the beta cells to secrete more insulin, but also causes the number of beta cells themselves to increase.

comments 0 comments - Posted Nov 18, 2007

Company Reports that Pig Cells are Producing Insulin in Two People

Living Cells Technologies (LCT) has announced that their Moscow trial of pig cell implantation, which began in June, is well underway: In September, the second of six type 1 patients was injected with 5,000 "islet equivalents per kilogram" of Diabecells into the peritoneal cavity.

comments 4 comments - Posted Nov 14, 2007

September 2007

An Oxygen Sandwich Helps Pancreatic Stem Cells Become Beta Cells
An Oxygen Sandwich Helps Pancreatic Stem Cells Become Beta Cells

Despite their best efforts, researchers have been having a hard time getting pancreatic stem cells to grow up into beta cells that can be used for transplantation.

comments 0 comments - Posted Sep 27, 2007

Fat: Pronounced Guilty in Death of Transplanted Beta Cells

When islet cells are transplanted into a person, they don't go into their usual home in the pancreas. Instead, they're injected into the portal vein, the large vein that feeds the liver with rich fats and sugars from the digestive system.

comments 0 comments - Posted Sep 15, 2007

July 2007

Pig Islets Transplanted into Human With Type 1 Diabetes

Recently we wrote that Living Cell Technologies (LCT), a New Zealand company, was about to begin transplanting pig islets into humans in a year-long Phase I/IIA clinical trial in Moscow, Russia ("Piglet Islets Soon Tested in Humans").

comments 1 comment - Posted Jul 12, 2007

June 2007

Cord Blood Stem Cells Engineered to Produce Insulin

Given that babies are born by the cartloads every day, cord blood is an easy source of fetal stem cells, especially because it’s free of the controversy surrounding embryonic stem cells.

comments 0 comments - Posted Jun 25, 2007

New Insulin-Secreting Beta Cells Come From Beta Cell Division, Not From Adult Stem Cells
New Insulin-Secreting Beta Cells Come From Beta Cell Division, Not From Adult Stem Cells

Researchers from Philadelphia have just discovered that beta cells, the insulin-producing cells of the pancreas, divide, albeit slowly, to make new beta cells. Adult stem cells, which are precursors of new skin, intestines, and other tissues, apparently do not differentiate into beta cells or other pancreatic tissue.

comments 1 comment - Posted Jun 2, 2007

May 2007

New Zealand Pig Islet Trial One Step Closer to Reality
New Zealand Pig Islet Trial One Step Closer to Reality

Eight New Zealanders with type 1 diabetes are hoping to receive pig islet transplantations by the end of the year, now that the company Living Cell Technologies (LCT) has surmounted the first of three regulatory hurdles in pursuit of permission for a twelve-month trial in New Zealand.

comments 0 comments - Posted May 15, 2007

April 2007

Joslin Diabetes Center-led Study Indicates Insulin Receptors Play a Critical Role in Promoting Islet Growth to Overcome Insulin Resistance

A recent Joslin-led study has identified the insulin receptor as an important protein that promotes islet cell growth in mice whose bodies are unable to use insulin properly, or are insulin resistant, a precursor to type 2 diabetes.

comments 0 comments - Posted Apr 23, 2007

Hope for a Type 1 Diabetes Cure? 15 Patients Off Insulin After Stem Cell Treatment
Hope for a Type 1 Diabetes Cure? 15 Patients Off Insulin After Stem Cell Treatment

Researchers from Sao Paulo in Brazil have announced that in a group of fifteen insulin-requiring, newly-diagnosed patients with type 1 diabetes, stem cell therapy has preserved beta cell function and eliminated the need for insulin for up to 35 months so far.

comments 4 comments - Posted Apr 12, 2007

Pig Islets Still Producing Insulin After Ten Years In Diabetic Man
Pig Islets Still Producing Insulin After Ten Years In Diabetic Man

Ten years ago, Michael Helyer, a New Zealand man with type 1 diabetes for eighteen years, received a transplant of pig islets. Much to the surprise of researchers, the pig cells are still putting out insulin at this late date. In fact, it was Mr. Helyer who alerted scientists at Living Cell Technologies (LCT) that the cells were still functioning.

comments 2 comments - Posted Apr 12, 2007

Dr. Hering Pig Islet Pioneer
Dr. Hering Pig Islet Pioneer

Dr. Bernhard Hering of the University of Minnesota is recognized the world over as the premier expert on pancreatic islet transplants. He sees islet transplantation as the best hope for the cure of type 1 diabetes, and his optimism is supported by his research.

comments 0 comments - Posted Apr 11, 2007

March 2007

Mighty Clean Pigs Ready to Supply Pancreatic Islets
Mighty Clean Pigs Ready to Supply Pancreatic Islets

In February 2007, one of the finest pig barns in the history of the world opened at a secret location in western Wisconsin. The $6.2 million, 21,000-square-foot Islet Resource Facility is a bio-secure facility for 100 “medical grade” pigs. A religious farming community, the Hutterian Brethren, is helping care for the pigs, which are barricaded from the outside world and pampered with filtered air, sterilized water, and decontaminated food.

comments 0 comments - Posted Mar 16, 2007

February 2007

Spring Point Project's Potential Diabetes Cure to Mark Another Major Milestone

MINNEAPOLIS, Minn. - For the millions of people worldwide who are afflicted with diabetes, we are now one step closer to a potential cure for the disease. Spring Point Project, a non-profit organization created to expedite the widespread availability of islet tissue for diabetes care, will open its first biosecure animal facility in Western Wisconsin in February to hold high-health pathogen-free pigs. Insulin-producing islet cells from pigs are needed to meet the demands that cannot be realized by using transplantation of human islets.

comments 0 comments - Posted Feb 28, 2007

Piglet Islets Soon Tested in Humans
Piglet Islets Soon Tested in Humans

Six people are about to receive pig islet transplantations for the first time, as a New Zealand company called Living Cell Technologies (LCT) begins a year-long Phase I/IIA clinical trial in Moscow, Russia.

comments 1 comment - Posted Feb 22, 2007

A Pony for A Cure
A Pony for A Cure

On January 27, in Phoenix, Arizona, ten-year-old Andrew gave up his beloved miniature horse, Zig Zag, to raise money for the Juvenile Diabetes Research Foundation (JDRF). He had to think about it hard; they’d been together since he was six. But he swallowed his sorrow and donated his pony to the JDRF’s gala auction because he believed “Zig Zag could help find a cure.”

comments 0 comments - Posted Feb 14, 2007

Company Takes Charge in Effort to Convert Embryonic Stem Cells to Islets

Novocell, Inc., a San Diego, California-based stem cell engineering company, announced on October 19, 2006, the development of a process that “efficiently converts human embryonic stem cells into insulin-producing pancreatic endocrine cells.”

comments 0 comments - Posted Feb 1, 2007

September 2005

Stem Cell Progress
Stem Cell Progress

In January 2005, the first implant of stem cells into the pancreas through a small artery was performed on a diabetic patient.

comments 0 comments - Posted Sep 1, 2005

August 2005

Pancreas Transplant Alone Improves Complications in Type 1s

Researchers in Italy say that ype 1s who undergo a successful pancreas transplant alone, without having a kidney transplant as well, have improved kidney function as well as restored normal blood glucose levels without the need for insulin therapy.

comments 0 comments - Posted Aug 1, 2005

March 2005

2005 Priorities for Diabetes: The U.S. Congress is Back in Session
2005 Priorities for Diabetes: The U.S. Congress is Back in Session

The U.S. Congress is back in session and hopes are high for diabetes victories.

comments 0 comments - Posted Mar 1, 2005

February 2005

Insulin Release in Embryonic Stem Cells
Insulin Release in Embryonic Stem Cells

Contrary to recent reports claiming that embryonic stem cells can generate insulin-producing cells, a Scandinavian study has found that this is not the case.

comments 0 comments - Posted Feb 1, 2005

January 2005

The Congressional Diabetes Caucus
The Congressional Diabetes Caucus

Representative George R. Nethercutt, Jr. (RWash.), formed the Congressional Diabetes Caucus in 1996 with only 22 supporters.

comments 0 comments - Posted Jan 1, 2005

August 2004

Stem Cells May Yield Unending Supply of Islets

It seems obvious that the limiting factor confronting islet transplantation is the scarce supply of insulin-producing islets.

comments 0 comments - Posted Aug 1, 2004

Spare $10 for a Diabetes Cure?
Spare $10 for a Diabetes Cure?

Lee Iacocca is mad as hell about the state of diabetes research and he doesn’t want to take it anymore.

comments 0 comments - Posted Aug 1, 2004

July 2004

The Devil We Know

“I’ve had diabetes for 35 years,” read one e-mail message to our Islet Service at DiabetesPortal.com. “I only have retinopathy and mild neuropathy, but I am having trouble feeling lows [hypoglycemia]. I want a cure that doesn’t require anti-rejection drugs.”

comments 0 comments - Posted Jul 1, 2004

May 2004

Single Islet Cell Infusion Success

A joint study by the University of Minnesota and the University of California San Francisco, with one islet cell infusion from a single donor pancreas, has achieved insulin independence in four of six people with longterm type 1 diabetes.

comments 0 comments - Posted May 1, 2004

Islet Transplants

A gene therapy technique could help islet transplants, but current anti-rejection drug therapy may hurt transplanted cells.

comments 0 comments - Posted May 1, 2004

April 2004

Risks and Benefits of Islet Transplantation

Islet transplantation offers promise, but it still shows risks of complications and loss of islet function over time.

comments 0 comments - Posted Apr 1, 2004

New Therapy Helps Freshly Isolated Islets Survive

Researchers in Italy and the United States collaborated to determine whether the peptide hormone glucagon-like peptide 1 (GLP-1) could improve function and inhibit programmed cell death or suicide.

comments 0 comments - Posted Apr 1, 2004

February 2004

Pancreas Transplant Improves Cardiac Function

A pancreas transplant can improve cardiac function in people with type 1 diabetes, according to Italian researchers.

comments 0 comments - Posted Feb 1, 2004

May 2003

A New Islet Source on the Horizon?

Researchers are speculating that human bone marrow may contain stem cells that are capable of differentiating into insulin-producing islet cells.

comments 0 comments - Posted May 1, 2003

January 2003

Transplanting Islets From Pigs to Humans

While everyone's attention has been drawn to the debate over stem cell research, another—perhaps more controversial—type of research is taking place.

comments 0 comments - Posted Jan 1, 2003

November 2002

Power Up - Synthetic Antioxidant Protects Islets

Adding a synthetic antioxidant compound to islets slated for transplantation preserves two to three times as many islets as in batches that do not receive the antioxidant, say researchers in Pittsburgh who are studying the process in mice. Antioxidants counteract damage that can be caused by oxygen in tissues.

comments 0 comments - Posted Nov 1, 2002

Power Up: Synthetic Antioxidant Protects Islets

Adding a synthetic antioxidant compound to islets slated for transplantation preserves two to three times as many islets as in batches that do not receive the antioxidant, say researchers in Pittsburgh who are studying the process in mice. Antioxidants counteract damage that can be caused by oxygen in tissues.

comments 0 comments - Posted Nov 1, 2002

October 2002

Pure and Simple

By 2004, every islet transplantation facility will have to be certified as a Good Manufacturing Practice (GMP) facility by the U.S. Food and Drug Administration (FDA). The Islet and Cellular Transplantation Center at the University of California, San Francisco (UCSF) is the first such facility to receive GMP certification—ensuring that the highest international standards are maintained for the isolation and purification of islets for transplantation.

comments 0 comments - Posted Oct 1, 2002

Pure and Simple-Islet Center First to Receive FDA Certification

By 2004, every islet transplantation facility will have to be certified as a Good Manufacturing Practice (GMP) facility by the U.S. Food and Drug Administration (FDA). The Islet and Cellular Transplantation Center at the University of California, San Francisco (UCSF) is the first such facility to receive GMP certification - ensuring that the highest international standards are maintained for the isolation and purification of islets for transplantation.

comments 0 comments - Posted Oct 1, 2002

May 2002

The Hype Surrounding Stem Cells

Some may think that it should be easy to cure diabetes: all you'd need would be an endless supply of islets, the pancreatic cells that produce insulin, to be transplanted into people with diabetes. But there are not nearly enough donated organs to go around, and, because the donated pancreas is actually someone else's organ, transplant patients need to take anti-rejection drugs for the rest of their lives.

comments 1 comment - Posted May 1, 2002

March 2002

Growing Islets

Researchers have begun nationwide clinical trials for a new treatment for diabetes based largely on the discoveries of a professor at Eastern Virginia Medical School (EVMS) in Norfolk.

comments 0 comments - Posted Mar 1, 2002

The Islet Transplant Versus the Artificial Pancreas

It's not exactly the tortoise versus the hare, but in the effort to get islet transplantation and a closed-loop artificial pancreas to the market, there seems to be a race.

comments 1 comment - Posted Mar 1, 2002

Are Pancreas Transplants Successful If You Have Had a Kidney Transplant?

Q: Are pancreas transplants very successful for someone who has had a previous successful kidney transplant? I have been considering a pancreas transplant, but several doctors have told me the success rates are not that good and that, in some cases, the individual develops a milder form of diabetes.

comments 0 comments - Posted Mar 1, 2002

February 2002

Big-Time Investment

The Juvenile Diabetes Research Foundation (JDRF) of New York, New York, has awarded a $15 million grant to the University of Alberta in Alberta, Canada. The five-year grant will be used to open an additional clinical research center dedicated to furthering Edmonton Protocol research by addressing some of the problems associated with islet cell transplantation.

comments 0 comments - Posted Feb 1, 2002

December 2001

The Diabetes Cure of Tomorrow

Someday, a cure for diabetes will be found. But the question still remains about it how it will happen. By regenerating our own cells? Or maybe by transplanting islets from pigs into humans?

comments 0 comments - Posted Dec 1, 2001

Edmonton Protocol Participants Speak

After 40 years on insulin, Bob Teskey, 56, could no longer keep his blood-glucose levels under control. As his condition worsened, his hypoglycemic (low blood-glucose) episodes became more and more intrusive on his life. Teskey talked to his doctors, but there was nothing they could do except tweak his insulin regimen, which did not solve the problem. He continued to collapse unexpectedly, as his blood-glucose levels dropped without warning.

comments 0 comments - Posted Dec 1, 2001

All in One Set of Hands

Islet Technology Inc., a research company based in St. Paul, Minnesota, has acquired all co-owned rights to patents related to encapsulated cell therapy.

comments 0 comments - Posted Dec 1, 2001

November 2001

For Islets Only

The Scripps-Whittier Diabetes Research Program at the University of California, San Diego, has announced that sometime in late 2002, it will create a new islet-research center focused on harvesting islets and transplanting them into humans. In addition, the new lab will perform research aimed at replicating islets to help solve the problem with donor shortages.

comments 0 comments - Posted Nov 1, 2001

October 2001

From Stems To Islets

On July 31, Israeli researchers turned human embryonic stem cells into a mass of islets which, in turn, produced insulin. However, the islets created from the stem cells did not shown that they could regulate insulin secretion based upon the body's glucose levels.

comments 0 comments - Posted Oct 1, 2001

September 2001

Type 1 Diabetes Cured Mice

A 40-day treatment of type 1 diabetes was shown to cure the disease in mice, say researchers from Massachusetts. The encouraging results could lead to finding a cure for diabetes in humans, they say.

comments 0 comments - Posted Sep 1, 2001

June 2001

Human Fat May Contain Stem Cells

According to UCLA doctors, human fat may be the latest discovery in the search for where stem cells could be harvested.

comments 0 comments - Posted Jun 1, 2001

May 2001

The Present and Future of Diabetes Research

In a special report published on February 7 by the Journal of the American Association entitled "Forecasting Opportunities in Medical Research," leaders in the medical research community outline the status of medical research today.

comments 0 comments - Posted May 1, 2001

April 2001

More Funding for Stem-Cell Research

January 31, Johns Hopkins University announced it had received a $58.5 million donation that will go toward the advancement of stem-cell research.

comments 0 comments - Posted Apr 1, 2001

80 Nobel Winners Speak Out in Favor of Embryonic Stem-Cell Research: Send Letter Urging President Not to Block Funds

In an effort to deter President Bush from blocking federal funds for embryonic stem-cell research, 80 U.S. Nobel laureates—among them DNA co-discoverers James Watson and Francis Crick, molecular biologist Hamilton O. Smith, and Edward Lewis—faxed a letter to the White House.

comments 0 comments - Posted Apr 1, 2001

March 2001

President Bush Hints Opposition to Embryonic Stem-cell Research

On January 26, President Bush all but announced he would oppose the use of federal funds for research using stem cells from aborted fetuses.

comments 0 comments - Posted Mar 1, 2001

Funding Embryonic Stem-Cell Research

According to a recent poll by the Juvenile Diabetes Research Foundation International (JDRF), twice as many Americans support federal funding of stem cell research than oppose it.

comments 0 comments - Posted Mar 1, 2001

Sheet of Islets - Edmonton Protocol Team Will Test Out New Transplant Method

On January 19, Islet Sheet Medical of San Francisco announced it has begun a collaborative research effort with Edmonton Protocol pioneers James Shapiro and Jonathan Lakey of the University of Alberta in Edmonton, Canada.

comments 0 comments - Posted Mar 1, 2001

January 2001

Now That Islet Transplants are All the Rage What are the Next Steps?

When Dr. James Shapiro sees teaspoons of freshly harvested islets floating in a fluid matrix at the bottom of a test tube, he sees "the difference between someone having diabetes—or not."

comments 0 comments - Posted Jan 1, 2001

What the Readers Think About Using Embryonic Stem Cells

Diabetes Health asked some of its readers to weigh in on the issue of using embryonic stem cells for diabetes research. Here is a sampling of what some people had to say:

comments 0 comments - Posted Jan 1, 2001

The Politics of Stem-cell Research-Where our Next President Stands

The landscape of embryonic stem-cell research could very well change when Texas Governor George W. Bush takes office later this month. The President can issue an executive order banning monies earmarked for specific research causes at NIH. He has the power to determine whether NIH can or cannot use funding for embryonic stem-cell research.

comments 0 comments - Posted Jan 1, 2001

What are Stem Cells?

According to the NIH Stem Cell Research Guidelines, human pluripotent stem cells are a unique scientific and medical resource, which can develop into most of the specialized cells and tissues of the body.

comments 0 comments - Posted Jan 1, 2001

Use of Stem Cells Heralded as Possible Cure for Diabetes—Ethics, However, Cause a Scientific and Political Controversy

In August 2000, the potential for finding a type 1 cure was championed when the National Institutes of Health (NIH) issued guidelines concerning the use of federal funds for research using stem cells from frozen human embryos.

comments 0 comments - Posted Jan 1, 2001

October 2000

Conference Yields New Crop of Ideas—JDF Reports Positive Results on Latest Beta-cell Efforts

At a three-day August conference held in Oxford, England, organized by the European Association for the Study of Diabetes and the JDF, researchers unveiled a variety of findings that might indicate a source for beta cells.

comments 0 comments - Posted Oct 1, 2000

September 2000

Planting the Seeds for an Artificial Pancreas

The Components of an Artificial Pancreas

comments 0 comments - Posted Sep 1, 2000

President Clinton Announces 10 New Transplant Sites - Revolutionary New Islet-transplant Procedure to Begin This Fall

On July 13, President Clinton announced the 10 centers chosen to replicate the Edmonton Protocol.

comments 0 comments - Posted Sep 1, 2000

Symposium Highlights, Building Blocks of an Artificial Pancreas

On June 6 and 7, academic and industry researchers joined in San Jose, California, for a two-day Artificial Pancreas Symposium. The tone of the conference was to discuss technology capable of monitoring glucose and automatically delivering the correct amount of insulin for the control of blood glucose in people with diabetes.

comments 0 comments - Posted Sep 1, 2000

August 2000

No More Diabetes: Scott King Interviews Islet-Transplant Expert About How He Did It

Recently, Dr. James Shapiro and a team of transplant surgeons at the University of Alberta in Edmonton transplanted islets into 10 people with type 1 diabetes. In previous studies, only eight percent of islet-transplant recipients have remained off insulin for one year. The Edmonton Protocol is the first study in which 100 percent of islet-transplant recipients have been insulin-independent for one year.

comments 1 comment - Posted Aug 1, 2000

Scientists Successfully Grow Beta Cells

Scientists at the University of California at San Diego recently announced that they have successfully grown beta cells that can produce insulin. The finding may eliminate one of the biggest obstacles in making islet transplantation a viable treatment for diabetes.

comments 0 comments - Posted Aug 1, 2000

Take Note: You Better Know Your Islets

If doctors were able to place healthy, insulin-producing islets into a person with diabetes in a minimally invasive procedure that needs to be repeated only occasionally, diabetes care as we know it would be finished. Patients might occasionally need insulin, and would of course want to keep an eye on their blood glucose levels, but the often-grueling regimen many of us now follow would be a thing of the past.

comments 0 comments - Posted Aug 1, 2000

July 2000

Bill Introduced in Congress to Cover Pancreas Transplants

On May 18, Congressional Diabetes Caucus co-chair George Nethercutt, R-Wash., and colleagues Reps. Lois Capps D-Ca., John Edward Porter R-Ill. and John LaFalce D-N.Y., introduced H.R. 4495. The bill, known as the Insulin-Free World Medicare Pancreas Transplantation Coverage Act, would provide Medicare coverage for all "medically necessary" pancreas transplants.

comments 0 comments - Posted Jul 1, 2000

June 2000

Short Review Of The Pancreas Transplant

The survival and success rates for pancreas transplants have improved during recent years. By 1997, almost 10,000 such transplants had been done.

comments 0 comments - Posted Jun 1, 2000

Artificial Pancreas Project Launched

The Disetronic Group has initiated and received approval for the development of an innovative new insulin delivery system with integrated monitoring of blood sugar.

comments 0 comments - Posted Jun 1, 2000

May 2000

Stem Cells Reverse Diabetes in Mice

In the March issue of the journal Nature Medicine, Ammon Peck, MD, and colleagues at the University of Florida in Gainseville, reported that the use of stem cells reversed diabetes in an animal model. Their experiment was the first to demonstrate that the cells were as valuable as researchers have speculated in treating diabetes.

comments 0 comments - Posted May 1, 2000

April 2000

Can Islets Regenerate? INGAP May Someday Cure Diabetes

Renowned researcher Aaron Vinik, MD, PhD, believes that the ability to generate new insulin-secreting islets from a patient's own pancreatic cells represents a potential cure for diabetes, without the need for antirejection medications.

comments 0 comments - Posted Apr 1, 2000

January 2000

Transplanted Islets Survive in Mismatched Donor - Bone Marrow Used

Researchers have successfully transplanted primate pancreatic islets into a mismatched diabetic primate without the need for long-term administration of anti-rejection drugs.

comments 0 comments - Posted Jan 7, 2000

Pancreas Tonic Looks for Credibility From Mainstream Diabetes Community

Pancreas Tonic, a new herbal treatment for people with diabetes, is drawing conflicting opinions from different quarters of the diabetes community. In 1999, Pancreas Tonic was hailed during an episode of the NBC television program EXTRA as "…the cure for diabetes" by William Taylor, MD, an internist. In additon, testimonials were given by people with diabetes who said that Pancreas Tonic really worked for the treatment of their blood sugars. According to transcripts from the EXTRA episode, Taylor added that Pancreas Tonic could be "one of the biggest medical breakthroughs of the century."

comments 3 comments - Posted Jan 1, 2000

December 1999

Novel Islet Transplant Drug is Suspended in Human Trials—Anti-CD154 Kept Diabetic Monkeys off Insulin

On October 21, Biogen announced that it was suspending several trials of its anti-CD154 drug because of blood clotting.

comments 0 comments - Posted Dec 1, 1999

Jackie Demijohn’s Life After Revolutionary Islet Transplantation

On September 11, 1998, Jackie Warren Demijohn, 42, a domestic violence outreach counselor from Farwell, Michigan, took a monumental leap in controlling the diabetes she had suffered from for the last 37 years. Demijohn underwent the first-ever islet and bone marrow transplant at the Diabetes Research Institute (DRI) in Miami.

comments 0 comments - Posted Dec 1, 1999

November 1999

What’s the Latest News on Islet Transplants?

I am president of a diabetes association in which we have lots of members who would like information on islet transplantation. What is the latest news on the success of islet transplantation?

comments 0 comments - Posted Nov 1, 1999

JDF, NIH Give Big Money to Link Islet Transplantation Centers

Two major enterprises toward successful islet transplantation were announced in October by the Juvenile Diabetes Foundation (JDF).

comments 0 comments - Posted Nov 1, 1999

October 1999

New Twist in Pig Transplant Controversy - Patients Show No Sign of Infection

The debate over the safety of transplanting pig islets into humans became even more controversial in late August. Researchers at the British biotechnology company Imutran Ltd. determined that 160 people from eight countries who carry living pig tissue showed no signs of Porcine Endogenous Retrovirus (PERV) infection. According to Associated Press (AP) news wire reports, 36 of the 160 patients had a high risk of PERV infection because they had very weak immune systems. The study, the largest yet of people treated with pig tissue, was confirmed by testing at the U.S. Centers for Disease Control and Prevention (CDC).

comments 0 comments - Posted Oct 1, 1999

Companies Continue on Road to Islet Transplantation

In the hopes that its islet-reproducing technology will soon be perfected, biotech company Desmos is partnering with other companies to work on technology that protects the islets after transplantation.

comments 0 comments - Posted Oct 1, 1999

August 1999

Catching Up with Miss America—Nicole Johnson Dreams of an Artificial Pancreas

DI: First, we have a message to pass along. Shannon Openshaw called us, from Bemidji, Minnesota. Her 11-year-old daughter, Adrienne, was diagnosed with diabetes in March. Shannon and Adrienne want to tell you that you gave her courage. She was feeling like she was going to have to give up a lot, but you changed that. They say, thanks.

comments 0 comments - Posted Aug 1, 1999

Business Venture Formed for Islet Transplantation

Two San Diego companies, Demos and Micro Islet, recently joined forces to advance islet transplantation. Desmos will make the islets, while Micro Islet will protect them once they've been transplanted.

comments 0 comments - Posted Aug 1, 1999

Micro- and Macroencapsulation: Firms Try Different Approaches to Protect Islets

Just as islet research is developing at the university level, corporations are taking steps toward creating devices and technologies to aid islet transplantation.

comments 0 comments - Posted Aug 1, 1999

The Holy Grail of Islet Research?

There's a buzz in the diabetes community from a recent islet transplantation success with a drug called anti-CD154. Given to monkeys once per month after islet transplants, anti-CD154 kept the islets working, and kept the monkeys free of insulin injections, and other harmful immunosuppressive drugs, for one year.

comments 0 comments - Posted Aug 1, 1999

First Lady Announces $120 Million Allocation for Islet Research

The federal government has said $120 million of the National Institutes of Health (NIH) allocated budget will be given to clinical trials of islet transplantation. On June 7, Hillary Rodham Clinton announced the allocation, and kicked off the Juvenile Diabetes Foundation Children's Congress in Washington.

comments 0 comments - Posted Aug 1, 1999

July 1999

JDF Grants $10 Million to 8 Islet Centers Worldwide

The Juvenile Diabetes Foundation (JDF) has granted another $10 million for islet transplant research. The money will be divided among eight centers worldwide, linking the knowledge of the top islet scientists.

comments 0 comments - Posted Jul 1, 1999

May 1999

Day of Hope

Miss America, Nicole Johnson, took time out at the "Day of Hope" to say hello to DIABETES HEALTH publisher Scott M. King. The "Day of Hope" was held March 27 in Palm Springs, California, as a diabetes product fair and research forum. It featured Miss America and three speakers from the diabetes business and research world. Alberto Hayek, MD, a leading islet researcher, announced that he is replicating beta cells 1 to 25,000, a true breakthrough on the road to islet transplantation. Another speaker, Scott R. King of Islet Sheet Medical, will collaborate with Hayek and use the replicated cells for his company's work in encapsulating islets for transplantation. Finally, Russell Potts, vice president at Cygnus, hopeful makers of a watch-like, noninvasive glucose monitor, presented his views on noninvasive blood testing.

comments 0 comments - Posted May 1, 1999

April 1999

Islet Capsule Lowers Blood Sugar Levels in Diabetic Rats

Researchers at Kyoto University in Japan have discovered a technique in which a capsule containing pancreatic cells can be implanted into a patient with a minor case of diabetes.

comments 0 comments - Posted Apr 1, 1999

Stem Cell Research Could Lead to Endless Islets - But Ethics Issues Cause Debate in Washington

The outcome of the contentious stem cell research debate in Washington will influence the future of islet transplantation.

comments 0 comments - Posted Apr 1, 1999

March 1999

NIH to Recruit Candidates for Islet and Kidney Transplant Study

As early as this summer, the National Institutes of Health (NIH) will begin recruiting candidates with type 1 diabetes for a new islet and kidney transplant study.

comments 0 comments - Posted Mar 1, 1999

February 1999

Company To Patent Important Islet Discovery

Researchers at The Scripps Research Institute (TSRI) have discovered technology that could be a big step toward islet transplantation. TSRI cannot give much information right now because it has not yet been published in a scientific journal. A TSRI representative expects publication soon.

comments 0 comments - Posted Feb 1, 1999

January 1999

The Fountain of Youth for Beta Cells?
The Fountain of Youth for Beta Cells?

PharmaTerra Inc. has staked a claim with its herbal remedy, ProBeta, which, if legitimate, could be the most profound treatment of diabetes to date.

comments 1 comment - Posted Jan 1, 1999

December 1998

A History of Antirejection Therapy and Pancreas Transplantation (1966-1998)

1966 First pancreas transplant performed at the University of Minnesota.

comments 0 comments - Posted Dec 1, 1998

October 1998

Farwell to a Pioneer in Animal Islet Transplantation

Dr. William L. Chick, a leading researcher in the fight against diabetes, died this past August at the age of 60.

comments 0 comments - Posted Oct 1, 1998

Desmos and UCLA Collaborate on Islet Program

Desmos Inc. has announced that it will continue to collaborate with Dr. Yoko Mullen at the University of California, Los Angeles, to support the development of its islet technology.

comments 0 comments - Posted Oct 1, 1998

September 1998

Healthy Islets for All - A Physician's Search for a Cure

For 15 years, Alberto Hayek, MD, has been conducting research on islet transplants, while also treating children with diabetes and teaching pediatric endocrinology at San Diego's Children's Hospital. Born in Colombia and educated at Yale and Harvard, Dr. Hayek is currently the lead investigator on islet cell transplantation at the Whittier Institute of La Jolla, California.

comments 0 comments - Posted Sep 1, 1998

August 1998

Dr. Soon-Shiong Sued by Mylan Laboratories

Mylan Laboratories Inc. has filed suit in a Los Angeles court against Patrick Soon-Shiong, MD, the well publicized islet cell transplant researcher at VivoRX.

comments 0 comments - Posted Aug 1, 1998

July 1998

A Seminar for Solutions - Searching for Future Treatments

I was among the 400 individuals who attended Today's Solutions for Type 1 Diabetes in St. Louis this past May. The seminar, organized and hosted by the Insulin-Free World Foundation, brought together leading researchers and those of us living with the disease to discuss current transplant options and possible future treatments.

comments 0 comments - Posted Jul 1, 1998

Islet Transplants Making Progress

In the late 1960s scientists started toying with the idea of replacing insulin producing cells (islets) to cure diabetes. These islets make up a mere one to two percent portion of the pancreas. The goal of this work is that eventually, one dose of insulin producing cells could last a lifetime and not require drugs to suppress the immune system.

comments 0 comments - Posted Jul 1, 1998

The Xenotransplantation Debate - Are Animal Islets More Harm than Good?

In 1984, the critically ill infant Baby Fae sparked debate with the news that a baboon heart had been implanted in her tiny body. Sadly, Baby Fae died 22 days later from complications of her illness.

comments 0 comments - Posted Jul 1, 1998

June 1998

Has the Pancreas Transplant Come of Age? -The Facts and Fiction

When the first pancreas transplant was performed in 1966 at the University of Minnesota, doctors considered it a risky venture at best. Three decades later and over a 1,000 people in the United States undergo a pancreas or simultaneous pancreas/kidney transplant every year. Still, a cloud of misinformation surrounds the procedure.

comments 0 comments - Posted Jun 1, 1998

February 1998

New Way to Stimulate Your Pancreas

Prandin (repaglinide), a new type 2 oral medication manufactured by Novo Nordisk, has been approved by the FDA.

comments 0 comments - Posted Feb 1, 1998

December 1997

Islet Cell Transplant Update

Q: What information do you have on the latest work being done on islet cell transplants for type I diabetics? When my 13-year-old daughter was diagnosed four and a half years ago, it seemed a cure was around the corner. Now it seems there are more obstacles than resolutions. Any hopeful information?

comments 0 comments - Posted Dec 1, 1997

October 1997

Farming Hearts, Livers and Pancreases?

What is on the horizon in organ transplants? Will hearts, livers, pancreases and kidneys be grown in a laboratory? Not in the near future, but doctors at Harvard have used cells from animal fetuses to produce new bladders and windpipes for sheep.

comments 0 comments - Posted Oct 1, 1997

September 1997

Pancreas Transplants Being Studied

Will Medicare pay for a pancreas transplant? The current answer is no. However, a new study under way by NIDDK will collect data to try to convince Medicare otherwise. The Health Care Financing Administration (HCFA) will use an NIDDK study of pancreas-kidney transplants to figure out when and under what circumstances, pancreas-kidney transplants are reasonable and necessary. These transplants would then be covered under the Medicare Program.

comments 0 comments - Posted Sep 1, 1997

August 1997

Is a Pancreas Transplant the Answer?

In this panel discussion, physicians presented the benefits of pancreas transplants for people with type 1 diabetes and the barriers to this type of therapy.

comments 0 comments - Posted Aug 1, 1997

June 1997

Gene Responsible for Islet Cell Regeneration Discovered

Researchers have recently discovered a gene that appears to be critical to the regeneration of islet cells. Lead researcher, Aaron Vinik, MD, PhD, admits that, " ... our findings are still preliminary and much more research in both animals and humans is needed." But based on work done on hamsters, it appears that the discovery could have the potential for regenerating islet cells in humans.

comments 0 comments - Posted Jun 1, 1997

April 1997

Wrap It Up I'll Take It

Islet cell transplants, a treatment that could reverse diabetes, is no longer a pipe dream. Success has been demonstrated in about 30 patients at a number of institutions worldwide.

comments 0 comments - Posted Apr 1, 1997

July 1996

Study Raises Questions About Dual Pancreas-Kidney Transplants

A study published in the December 1995 issue of Lancet, indicating a dual pancreas-kidney transplant may be more dangerous than previously suspected, has stirred controversy at the University of Minnesota.

comments 0 comments - Posted Jul 1, 1996

April 1996

FDA Cracks Down On Loran Medical, Controversial Injections Stop

In response to a warning from the FDA, Loran Medical Systems has suspended its controversial trials which involve injecting people with diabetes with fetal and rabbit pancreatic cells. The warning, issued January 4th, states that Loran violated regulations that govern the importing of biological products and the conducting of clinical trials. Critics have called the company's procedure, which costs $20,000, unproven and ineffective.

comments 0 comments - Posted Apr 1, 1996

January 1996

Encapsulated Islets—Different Techniques Being Studied

The goal of all islet encapsulation research is to prevent the need for immunosuppressive drugs. These drugs prevent the immune system from attacking the new islet cells but cause serious complications of their own. Encapsulation technology involves enclosing insulin-producing islet cells in a semi-permeable membrane that allows small molecules, like glucose, insulin, and nutrients to pass but prevents larger immune-system molecules from entering.

comments 0 comments - Posted Jan 1, 1996

Study Shows Pancreas Size Decreases More Than 30% In Kids With Diabetes

Although §-cells comprise just two percent of the gland, a study has found that children with diabetes have smaller pancreases than their healthy peers.

comments 0 comments - Posted Jan 1, 1996

October 1995

Costlier Than Caviar: Imported Russian Fetal Cell Transplants For $20,000 Generating Controversy

A company in Southern California has become the center of debate within the diabetes community. The company, Loran Medical Systems, is conducting studies involving fetal pancreatic tissue. More unusual than the science is the fact that patients are paying thousands of dollars to participate in clinical trials.

comments 0 comments - Posted Oct 1, 1995

September 1995

Who Gets That Pancreas? The FDA Wonders, Too

The Food and Drug Administration is beginning to worry about how to regulate cells and organs for transplant, something that has traditionally been left to doctors to decide.

comments 0 comments - Posted Sep 1, 1995

Take Note: You Better Know Your Islets

It seems like fantasy, something the doctors on Star Trek would have in their repertoire. But this is not science fiction-as we hurtle toward the 21st century, researchers are racing toward a practical method of islet transplantation, the procedure that could revolutionize diabetes treatment.

comments 0 comments - Posted Sep 1, 1995

Some Days He Takes No Insulin

The transplantation of pancreatic islet cells is the only known potential cure for type I diabetes, and in spite of many promising results in animal studies, it remains a highly experimental and costly operation for humans. In January 1994, DIABETES HEALTH spoke to Steven Craig, the first person to receive encapsulated islet cell transplants.

comments 2 comments - Posted Sep 1, 1995

Some Exciting Patents

In a reaction to research that shows a relationship between infant consumption of cow's milk and the development of diabetes, Nutrition Concepts Inc. proposes a method of making milk "safe."

comments 0 comments - Posted Sep 1, 1995

July 1995

Patent Watch

Pancreas Implant

comments 0 comments - Posted Jul 1, 1995

June 1995

Islets, When are They Available? With Time Line Chart

Islet Transplantation - Available When?
In our April issue, Mr. Metabolism (Scott Robert King) wrote about the evolution of the islet transplant industry and invited questions. He has received several queries. These came through the Internet:

comments 0 comments - Posted Jun 1, 1995

May 1995

Islet transplant business moves forward with new financing and talent

The Neocrin Company is presently one of the leading biomedical companies involved in the research and development of a bio-artificial pancreas. This minimally invasive implantable device will be used for the treatment of insulin dependent diabetes.

comments 0 comments - Posted May 1, 1995

April 1995

Islet Transplantation: Businesses Are Booming

Even well-informed people with diabetes may not appreciate how many businesses have been found-ed to profit from the sale of islets to treat people suffering with Insulin Dependent Diabetes Mellitus.

comments 0 comments - Posted Apr 1, 1995

March 1995

Attacks On Islets by the Body Explored by Julia McFarlane Diabetes Research Centre

An attempt to discover why the body decides to attack islets in people with diabetes was made by the researchers at the Julia McFarlane Diabetes Research Centre.

comments 0 comments - Posted Mar 1, 1995

Islet Tranplantation Study Comes Up Short

Islet transplantation has the potential to be the miracle cure so many people with diabetes are seeking. However, research done at John Radcliffe Hospital shows that the cure might be a long way off.

comments 0 comments - Posted Mar 1, 1995

March 1994

Mr. Metabolism’s Views On This Months Research News

Mr. Metabolism loves to follow new developments in diabetes research—in fact, that's one of the ways he makes his living. The following brief summaries give Mr. Metabolism's views on the Research Reports in the latest issue of DIABETES HEALTH.

comments 0 comments - Posted Mar 1, 1994

Smaller Pancreases In Diabetics

Using ultrasonography, researchers at the Armed Forces Hospital in Riyadh, Saudi Arabia have discovered that people who suffer from insulin deficiency, in either type I or insulin treated type 2 diabetes, have markedly smaller pancreases than non-diabetic control subjects and people with sulfonylurea treated type 2 diabetes.

comments 0 comments - Posted Mar 1, 1994

November 1993

Clinical Trial of Encapsulated Islet Cells

On August 16th, CytoTherapeutics Incorporated announced the commencement of its FDA-approved trial involving polymer-encapsulated islet cells. The trial is designed to establish that their semi-permeable membrane can allow enough nutrients through to keep the encapsulated cells alive while protecting them from destruction without the use of immunosuppressive drugs. The implant will be tested in people with type I and type 2 diabetes, as well as in a nondiabetic control group. The trial will be conducted at Washington University School of Medicine in St. Louis, and results of the 4 month viability study are expected by the end of 1993.

comments 0 comments - Posted Nov 1, 1993

August 1993

Successful Islet Cell Transplants in Italy

An Italian research team reports the success of islet cell transplant experiments conducted on ten patients with Type I diabetes. All of the patients involved in the experiments were immunosuppressed, and received islet cells in conjunction with kidney or liver transplants. In total, over 70% of the patients who received islet cells no longer required insulin therapy.

comments 0 comments - Posted Aug 1, 1993

June 1993

Islet Cells Transplanted: Mr. Metabolism’s Response

Mr. Metabolism has received numerous questions concerning the first human clinical trial of encapsulated islets announced on the CBS Evening News Thursday, May 13.

comments 0 comments - Posted Jun 1, 1993

First Human Encapsulated Islet Cells Transplanted

Los Angeles, CA, May 13, 1993 - The first encapsulated pancreatic islet cell transplant in humans was reported today by physician scientists of the National Institute of Transplantation at St. Vincent Medical Center, Los Angeles.

comments 0 comments - Posted Jun 1, 1993

February 1993

Artificial Pancreas May Be the Future of Diabetes Treatment

New developments in materials, bio-engineering techniques and other disciplines have recently taken the concept of artificial organs from fantasy to reality. EU 346 PANART-Artificial Pancreas, for example, aims to develop an implanted artificial insulin delivery system, which promises to give diabetes sufferers a more normal and healthy lifestyle.

comments 0 comments - Posted Feb 1, 1993

January 1993

Ask Mr. Metabolism

This month Mr. Metabolism considers the case of Dr. Hu (pronounced "Dr. Who"), prompted by a reader's inquiry.

comments 0 comments - Posted Jan 1, 1993

November 1992

Is Fetal Tissue the Answer for Finding a

Fetal tissue. No other topic in diabetes research is as emotionally stirring. Some say that fetal tissue is the key to progress, and perhaps that fetal tissue will even cure diabetes. Others claim that fetal tissue research is immoral because it produces an incentive for abortions. How important is fetal tissue research? Is it likely to produce a cure for diabetes? Are there alternatives that avoid ethical concerns?

comments 0 comments - Posted Nov 1, 1992

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