It's generally thought that a genetic predisposition to type 1 diabetes is not enough to develop the disease, but that an environmental trigger is required to activate it. Researchers are not sure what that environmental trigger is, but enteroviruses have been under suspicion for quite a while. Enteroviruses are the second leading cause of viral colds in children.
(Reuters) - Stem cells can be transformed into the pancreatic cells needed to treat diabetes and into complex layers of intestinal tissue, scientists demonstrated in two experiments reported on Sunday.
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Diabetes research is on the cusp of new advances in treatment options and in understanding the underlying causes of both type 1 and type 2 diabetes. Among those are potential treatments using stem cells to regenerate a patient's ability to produce insulin, as well as upcoming clinical trials of a vaccine that potentially could prevent type 1 diabetes.
MannKind Corporation announced that the company will supply its novel, ultra rapid acting insulin AFREZZATM (insulin human [rDNA origin]) for use in a study being conducted by the Juvenile Diabetes Research Foundation (JDRF) as part of its Artificial Pancreas Project. The planned two-year study in patients with type 1 diabetes will leverage the unique rapid action of AFREZZA for use in a closed-loop blood sugar monitoring and insulin delivery system, termed the "artificial pancreas" by the JDRF. The study will be managed in conjunction with the Sansum Diabetes Research Institute and the University of California, Santa Barbara.
City of Hope researchers have found that bone marrow transplantation with islet cell transplantation shows promise as a treatment for late-stage type 1 diabetes. This combination may enable patients to make their own insulin again. Results from laboratory research led by Defu Zeng, MD, associate professor in the departments of Diabetes Research and Hematology & Hematopoietic Cell Transplantation at City of Hope, were published online this month in the journal Diabetes.
Osiris Therapeutics announced that it has been granted Orphan Drug designation from the U.S. Food and Drug Administration (FDA) for Prochymal as a treatment for type 1 diabetes mellitus. The FDA instituted the Orphan Drug Act to promote the development of treatments for underserved patient populations. To be eligible for Orphan Drug designation, the treatment must target a disease that affects fewer than 200,000 new patients per year in the United States.
You may not have heard of GAD, but it's a hot topic in the world of type 1 diabetes research. GAD, which stands for glutamic acid decarboxylase, is an enzyme in the brain and the pancreas that plays several roles in the body. As an enzyme, it converts the excitatory amino acid glutamate into the inhibitory neurotransmitter GABA, which nerve cells use to communicate. But it also has a less helpful role, as an autoantigen (an element of self that provokes the generation of antibodies) in autoimmune diabetes.
WASHINGTON, Dec. 15 /PRNewswire-USNewswire/ -- A 21-year old Airman severely wounded in Afghanistan is recovering at Walter Reed Army Medical Center after several surgeries and an unprecedented transplant.
"Medical miracles do not happen simply by accident," said President Obama, as he signed an executive order lifting the ban on federally funded embryonic stem cell research. The Juvenile Diabetes Research Foundation (JDRF) is celebrating President Obama's new policy. They recently released this statement by Mary Tyler Moore, the International Chairman of the JDRF:
Non-beta "progenitor" cells in the pancreas can be stimulated to turn into beta cells even after birth or autoimmune injury to the pancreas, say researchers at Joslin Diabetes Center in Boston, an affiliate of Harvard Medical School.
Diabetes Health has always been ambivalent when it comes to reporting diabetes research that involves mice. For one thing, although the critters are mammals, it's a stretch to say that what happens in a mouse can be duplicated in a human.
Twenty-four diabetes doctors and researchers from the United States, Canada, the United Kingdom, Finland, Sweden and Portugal have published a study criticizing the American Diabetes Association (ADA) assertion that diabetics should consume no fewer than 130 mg of carbohydrates daily and the European Association for the Study of Diabetes (EASD) statement that low-carb diets are “not justified.”
The blood pressure medicine Tekturna (aliskiren) may have a beneficial side effect for people with type 2 diabetes and high blood pressure who are at risk of kidney disease. According to a recent article in The New England Journal of Medicine, the drug reduces proteinuria, a key indicator of kidney disease, by 20 percent in patients with type 2 diabetes.
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