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Beta Cells Archives

Diabetes and Beta Cells

Page 3
Stem Cell Treatment for Type 1 Diabetes

Osiris Therapeutics announced that it has been granted Orphan Drug designation from the U.S. Food and Drug Administration (FDA) for Prochymal as a treatment for type 1 diabetes mellitus. The FDA instituted the Orphan Drug Act to promote the development of treatments for underserved patient populations. To be eligible for Orphan Drug designation, the treatment must target a disease that affects fewer than 200,000 new patients per year in the United States.

Comments 0 comments - May 7, 2010 - * * * * *

Insulin-Producing Cells Derived from Specially Bred Pigs

NEW YORK, April 27, 2010 - The Juvenile Diabetes Research Foundation announced today that it is partnering with Living Cell Technologies (LCT), a New Zealand-based biotechnology company focused on developing cell based therapeutics, in a Phase II clinical trial to study the safety and effectiveness of transplanting encapsulated insulin-producing cells from pigs as a treatment for type 1 diabetes with significant hypoglycemia unawareness.

Comments 1 comment - Apr 28, 2010 - * * * * *

Artificial Pancreas for Type 1 Diabetes Works in Clinical Trials

The first human trials of the latest design of an artificial pancreas for people with type 1 diabetes found the device worked without causing low blood sugar (hypoglycemia).

Comments 8 comments - Apr 18, 2010 - * * * * *

Insulin-Producing Beta Cells Can Be Reborn

Healthy, insulin-producing beta cells in the pancreas have a relatively long life and typically do not replicate under normal conditions. Any loss of beta cells, therefore, is usually permanent. In the case of type 1 diabetes, for example, the destruction of beta cells by the body's own immune system is permanent.

Comments 2 comments - Apr 9, 2010 - * * * * *

The Story of GAD

You may not have heard of GAD, but it's a hot topic in the world of type 1 diabetes research. GAD, which stands for glutamic acid decarboxylase, is an enzyme in the brain and the pancreas that plays several roles in the body. As an enzyme, it converts the excitatory amino acid glutamate into the inhibitory neurotransmitter GABA, which nerve cells use to communicate.  But it also has a less helpful role, as an autoantigen (an element of self that provokes the generation of antibodies) in autoimmune diabetes.

Comments 4 comments - Mar 23, 2010 - * * * * *

Discovery of a Suspect Enzyme in Humans Could Lead to Powerful Type 1 Therapy

An enzyme that destroys pancreatic beta cells in lab mice has now been observed in human beta cells. Because scientists already know how to delete the mouse gene that produces the enzyme, they are hopeful that the same therapy can eventually be applied to people with type 1 diabetes. If so, it would be one of the most powerful therapies yet for addressing the destruction of insulin-producing beta cells that causes type 1.

Comments 4 comments - Mar 1, 2010 - * * * * *

JDRF-Funded Research Advances Potential for Regeneration as a Possible Cure for Type 1 Diabetes

A hormone responsible for the body's stress response is also linked to the growth of insulin-producing cells in the pancreas, according to JDRF- funded researchers at the Salk Institute for Biological Studies in California. The findings are the latest advances to underscore the potential for regeneration as a key component of a possible cure for type 1 diabetes.

Comments 2 comments - Feb 22, 2010 - * * * * *

Researchers Discover Protein that Triggers Islet Cell Rejection

Researchers at RIKEN and Fukuoka University have pinpointed the mechanism responsible for early rejection of transplanted pancreatic islet cells in the treatment of type 1 diabetes. A new system based on this mechanism has been shown to vastly increase transplant efficiency, setting the stage for the development of powerful new treatment techniques.

Comments 5 comments - Feb 9, 2010 - * * * * *

Skin cells transformed directly into nerve cells: Are beta cells next?

WASHINGTON (Reuters) - Researchers have transformed ordinary mouse skin cells directly into neurons, bypassing the need for stem cells or even stemlike cells and greatly speeding up the field of regenerative medicine.

Comments 0 comments - Jan 29, 2010 - * * * * *

Newly identified genes influence insulin and glucose regulation

An international research consortium has found 13 new genetic variants that influence blood glucose regulation, insulin resistance, and the function of insulin-secreting beta cells in populations of European descent. Five of the newly discovered variants increase the risk of developing type 2 diabetes, the most common form of diabetes.

Comments 2 comments - Jan 23, 2010 - * * * * *

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