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Of all the quests that researchers have undertaken in search of a cure or decisive treatment for type 1 diabetes, the search for a vaccine has to be the boldest. But how would you develop such a vaccine, and how would it work?
2 comments - Jul 9, 2009 -
Researchers funded by the Juvenile Diabetes Research Foundation have found two chemical compounds that can trigger the growth of insulin-producing beta cells in the pancreas. The discovery could become the basis for medicines designed to regenerate the pancreas in people with type 1 diabetes.
9 comments - Mar 11, 2009 -
Talk of a cure has been around forever. Sometimes it seems as if the cure is a constantly receding dream, always ten years away or just around the next corner.
12 comments - Mar 9, 2008 - Not Yet Rated
A team of five seniors and two freshmen at Johns Hopkins University has devised a little "pouch" to hold microcapsules of beta cells in the portal vein, from which the cells can send out insulin while safely protected inside. It's made by sandwiching a porous cylinder of nylon mesh between two cylindrical metal stents, similar to the ones that are used to keep clogged blood vessels open.
0 comments - Jul 23, 2007 -
A new study out of London and Paris indicates in the developing embryo, beta cells form in the pancreas in response to the presence of glucose. Glucose triggers a gene called Neurogenin3 to switch on another gene, neuroD, which is critical for the normal development of beta cells. If glucose levels are low, the gene doesn't switch on and the beta cells don't develop.
0 comments - Jun 18, 2007 - Not Yet Rated
A team of five seniors and two freshman at Johns Hopkins University has devised a little “pouch” to hold microcapsules of beta cells in the portal vein, from which the cells can send out insulin while safely protected inside.
0 comments - May 18, 2007 - Not Yet Rated
Novocell, Inc., a San Diego, California-based stem cell engineering company, announced on October 19, 2006, the development of a process that “efficiently converts human embryonic stem cells into insulin-producing pancreatic endocrine cells.”
0 comments - Feb 1, 2007 - Not Yet Rated
Procter & Gamble Pharmaceuticals is sponsoring a new study on the safety and efficacy of INGAP-peptide.
0 comments - Mar 1, 2004 - Not Yet Rated
Five years ago, when Dana Elias, PhD, first clutched a publication reporting that a synthetic peptide had halted beta-cell destruction in mice that already were showing high blood-glucose levels, she felt a shiver of excitement. She had helped develop the synthetic peptide, called DiaPep277.
0 comments - Feb 1, 2002 -
The precursor to insulin produced by the pancreas's beta cells is a peptide chain known as proinsulin. Made up of amino acids bound into a u-shape by a connecting polypeptide, proinsulin is stored in beta cells until a glucose load demands the release of insulin. At this point, the connecting molecule is broken off the bottom of the "u"-its shape earning it the moniker C-peptide-freeing the insulin molecule for secretion.
0 comments - Sep 1, 2000 - Not Yet Rated
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