Diabetes and Beta Cells
Glucose Triggers the Development of Embryonic Beta Cells
Linda von Wartburg |
Jun 18, 2007 |
A new study out of London and Paris indicates in the developing embryo, beta cells form in the pancreas in response to the presence of glucose. Glucose triggers a gene called Neurogenin3 to switch on another gene, neuroD, which is critical for the normal development of beta cells. If glucose levels are low, the gene doesn't switch on and the beta cells don't develop.
Students Invent a Protective Pouch to Hold Transplanted Beta Cells
Linda von Wartburg |
May 18, 2007 |
Company Takes Charge in Effort to Convert Embryonic Stem Cells to Islets
D. Trecroci |
Feb 1, 2007 |
Novocell, Inc., a San Diego, California-based stem cell engineering company, announced on October 19, 2006, the development of a process that “efficiently converts human embryonic stem cells into insulin-producing pancreatic endocrine cells.”
A New 'Morning-After' Diabetes Shot Stops Beta-Cell Destruction in Adults
Jan Chait |
Feb 1, 2002 |
Five years ago, when Dana Elias, PhD, first clutched a publication reporting that a synthetic peptide had halted beta-cell destruction in mice that already were showing high blood-glucose levels, she felt a shiver of excitement. She had helped develop the synthetic peptide, called DiaPep277.
What is the C-peptide Test?
Thomas Connors |
Sep 1, 2000 |
The precursor to insulin produced by the pancreas's beta cells is a peptide chain known as proinsulin. Made up of amino acids bound into a u-shape by a connecting polypeptide, proinsulin is stored in beta cells until a glucose load demands the release of insulin. At this point, the connecting molecule is broken off the bottom of the "u"-its shape earning it the moniker C-peptide-freeing the insulin molecule for secretion.
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