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Medications Research Archives

Diabetes Medications Research

Page 4
Smart Insulin

A team of researchers from Case Western University published an article revealing their invention of a "smart" insulin molecule that binds considerably less to cancer receptors and self-assembles under the skin. To provide a slow-release form of insulin, the compound self-assembles under the skin by "stapling" itself together with zinc ions. Zinc staples connect the pieces of the insulin puzzle together to create a functional protein.

Comments 0 comments - Apr 23, 2010 - * * * * *

Diabetes Drug Tied to Reduced Breast Cancer Risk

The study, published in the journal Diabetes Care, adds to evidence that metformin, a generically available drug commonly used for type 2 diabetes, may have anti-cancer effects.

Comments 0 comments - Apr 22, 2010 - * * * * *

Synthetic Molecule That Stops Diabetic Inflammation Could Become a Type 2 Therapy

Tests of an experimental drug called CPSI-1306 at Ohio State University were so successful at lowering inflammation and blood sugar levels in lab mice with type 2 diabetes that scientists consider it a prime candidate to become a new therapy for the disease. 

Comments 0 comments - Apr 8, 2010 - * * * * *

The Story of GAD

You may not have heard of GAD, but it's a hot topic in the world of type 1 diabetes research. GAD, which stands for glutamic acid decarboxylase, is an enzyme in the brain and the pancreas that plays several roles in the body. As an enzyme, it converts the excitatory amino acid glutamate into the inhibitory neurotransmitter GABA, which nerve cells use to communicate.  But it also has a less helpful role, as an autoantigen (an element of self that provokes the generation of antibodies) in autoimmune diabetes.

Comments 4 comments - Mar 23, 2010 - * * * * *

Valsartan (Diovan) Delayed Progression to Type 2 Diabetes in At-Risk Cardiovascular Patients With Impaired Glucose Tolerance

Results from a landmark study involving more than 9,000 people showed that the high blood pressure medicine valsartan (Diovan) delayed progression to type 2 diabetes in patients with cardiovascular disease or risk factors and impaired glucose tolerance (IGT), a common pre-diabetic condition.

Comments 0 comments - Mar 20, 2010 - * * * * *

Mutation That Affects Response to Smell and Taste Could Lead to Type 2 Diabetes

According to Duke University researchers, a mutation that causes the lack of an insulin-controlling molecule may be a factor in the development of type 2 diabetes. The molecule, ankyrin B, is activated in response to the smell and taste of food and leads to the production of insulin in preparation for food intake.

Comments 1 comment - Mar 19, 2010 - * * * * *

Dolphins' Ability to Switch Diabetes On and Off Could Point to a Similar Knack in Humans

A scientist's discovery that dolphins have a genetic ability to turn diabetes on and off, depending on the availability of food, could lead to research into whether humans might have a similar-although dormant-gene.

Comments 1 comment - Mar 13, 2010 - * * * * *

Northern California's Biggest County Sues Glaxo Over Avandia

Santa Clara County, the largest county in Northern California (nearly 1.9 million people), has filed a federal lawsuit against pharmaceutical company GlaxoSmithKline, alleging that Glaxo knowingly sold its type 2 diabetes drug Avandia for several years despite indications the drug causes heart attacks and strokes.

Comments 0 comments - Mar 8, 2010 - * * * * *

GSK rejects conclusions of Senate Committee on Finance Staff Report on Avandia

The Staff Report of the Senate Committee on Finance draws conclusions on the safety of Avandia (rosiglitazone) that are based on analyses that are not consistent with the rigorous scientific evidence supporting the safety of the drug. In addition, the report cherry-picks information from documents, which mischaracterizes GlaxoSmithKline's comprehensive efforts to research Avandia and communicate those findings to regulators, physicians and patients. In fact, the safety and effectiveness of Avandia is well characterized in the label approved by the FDA.

Comments 1 comment - Feb 23, 2010 - * * * * *

U.S. Senate Report Says Glaxo Knew that Avandia Increases Risk of Heart Attacks

A U.S. Senate Finance Committee report released on February 20 says that Avandia, GlaxoSmithKline's drug for type 2 diabetes, may have caused as many as 83,000 heart attacks between 1999, when the drug was introduced, and 2007. The Senate report, culminating a two-year inquiry into the drug, also says that Glaxo knew about the drug's potential risks years before suspicions began to form regarding a connection between Avandia and heart problems.

Comments 2 comments - Feb 22, 2010 - * * * * *

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