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Insulin-dependent diabetes mellitus is associated with altered electrolyte metabolism and a derangement of the parathyroid hormone (PTH)-vitamin D endocrine system. Twenty three children with diabetes were found to have lower serum values for calcium, magnesium, PTH, calcitriol, and osteocalcin than age- and sex-matched control subjects without diabetes. After patients were given magnesium orally (6mg/kg daily) for up to 60 days, concentrations significantly increased, reaching control values.
The data suggests that magnesium deficiency plays a pivotal role in altering mineral homeostasis in insulin dependent diabetes mellitus (Journal of Pediatrics, February 1991).