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Syndrome X is a group of problems associated with type 2 diabetes. It includes obesity, hypertension (high blood pressure), hyperlipi-demia (abnormal cholesterol metabolism), macro-angiopathy, (large blood vessel disease/hardening of the arteries), and insulin resistance.
In a study conducted by C. Zoupas in Greece, it was found that metformin may be the key to treating Syndrome X. By adding metformin to insulin regimens, type 2 patients experienced improved glycemic control and reduced cholesterol, weight, blood pressure, and insulin requirements.
According to Zoupas' report, "Metformin and insulin is the treatment of choice in type 2 patients with Syndrome X and secondary failure to oral agents (sulfonylureas)."
Editor's note: Dr. Bernstein, of our medical advisory board, notes that incidence of stomach upset from metformin can usually be avoided by starting dosage at 250 mg/day and increasing it slowly over a period of months.
This research was presented at the 22nd Annual Meeting and Educational Program of the AADE in Boston, August 1995.
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.