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Fluoxetine is the generic name for Prozac, the increasingly-popular antidepressant drug. A study published in Diabetic Medicine, May 1995, reported that fluoxetine may help elderly people with type 2 diabetes lose weight.
A double-blind study of 30 obese type 2 patients over age 60 was conducted in Glasgow, Scotland. Those taking fluoxetine lost an average of 5.72 pounds after three months compared with almost zero weight loss in the placebo group.
According to the report, "Improved glycemic control was also demonstrated in the fluoxetine group compared with placebo, initial A1c levels of 8.0% vs. 8.7% falling at six months by 0.9%."
Although no sustained improvement in fasting blood glucose occurred, it was evident that fluoxetine aided short-term weight loss without adverse effects. However, The Physician's Desk Reference indicates that, "In patients with diabetes, [fluoxetine] may alter glycemic control. Hypoglycemia has occurred during therapy with fluoxetine and hyperglycemia has developed following discontinuation of the drug. As is true with many other types of medication, when taken concurrently by patients with diabetes, insulin and/or oral hypoglycemic dosage many need to be adjusted when therapy with fluoxetine is instituted or discontinued."
The PDR Family Guide to Prescription Drugs warns patients, "Unless you are directed to do so by your doctor, do not take [fluoxetine] if you are recovering from a heart attack or if you have kidney or liver disease, or diabetes."
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