Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12 Tips for Traveling With Diabetes
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter
Latest
Popular
Top Rated
Diabetes Health Reference Charts
Insulin Archives
Print | Email | Share | Comments (0)

Insulin and Metformin Before Bed Proven Effective for Poorly Controlled Type 2s—Drops HbA1cs from 9.7% to 7.2%


May 1, 1999

In a study conducted in Finland, it was discovered that insulin combined with metformin (Glucophage) taken at bedtime appears to be an effective regimen for controlling type 2 diabetes.

The results of the study were published in the March 2 issue of the Annals of Internal Medicine. Finnish investigators report the results of a direct comparison of four bedtime insulin regimens that were randomly assigned to 96 patient with type 2 diabetes. The patients had previously been treated by sulfonylurea therapy alone, and had demonstrated an average HbA1c of 9.9 % and an average BG reading of 214.5 mg/dl.

For 12 months, the 96 patients took a combination of either: (1) bedtime intermediate-acting insulin plus glyburide (10.5 mg.) and placebo, (2) metformin (2 grams) and placebo, (3) glyburide and metformin, or (4) a second injection of intermediate-acting insulin in the morning.

After 13 months, the group taking the combination of intermediate-acting insulin and metformin demonstrated the greatest decrease in HbA1c (9.7 % to 7.2 %). Additionally, this group reported fewer cases of hypoglycemia after one year when compared to the other groups.


Categories: A1c Test, Diabetes, Insulin, Low Blood Sugar, Metformin, Type 2 Issues



You May Also Be Interested In...


Comments


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...


Username: Password:
Comment:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.