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Insulin and Metformin Before Bed Proven Effective for Poorly Controlled Type 2s—Drops HbA1cs from 9.7% to 7.2%
In a study conducted in Finland, it was discovered that insulin combined with metformin (Glucophage) taken at bedtime appears to be an effective regimen for controlling type 2 diabetes.
The results of the study were published in the March 2 issue of the Annals of Internal Medicine. Finnish investigators report the results of a direct comparison of four bedtime insulin regimens that were randomly assigned to 96 patient with type 2 diabetes. The patients had previously been treated by sulfonylurea therapy alone, and had demonstrated an average HbA1c of 9.9 % and an average BG reading of 214.5 mg/dl.
For 12 months, the 96 patients took a combination of either: (1) bedtime intermediate-acting insulin plus glyburide (10.5 mg.) and placebo, (2) metformin (2 grams) and placebo, (3) glyburide and metformin, or (4) a second injection of intermediate-acting insulin in the morning.
After 13 months, the group taking the combination of intermediate-acting insulin and metformin demonstrated the greatest decrease in HbA1c (9.7 % to 7.2 %). Additionally, this group reported fewer cases of hypoglycemia after one year when compared to the other groups.
Categories: A1c Test, Diabetes, Insulin, Low Blood Sugar, Metformin, Type 2 Issues
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May 1, 1999
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Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
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