Open 24 Hours — Once-Per-Day Basal Insulin Submitted to FDA

| Jul 1, 1999

One shot per day of long-acting insulin may be all that you need in the future, if the U.S. Food and Drug Administration (FDA) approves Hoechst's insulin glargine, a 24-hour basal insulin.

Hoechst submitted a new drug application in the United States and Europe during May. It could take as long as one year before the FDA makes a ruling.

"Patients loved it," says John Buse, MD, PhD, CDE, of the people who participated in the clinical trials he conducted for Hoechst. Buse directs the University of North Carolina's Diabetes Center.

Most of the people who participated in the clinical trials were not doing well on NPH or Ultralente, but, according to Buse, insulin glargine improved their control.

"They're upset that they cannot continue on it," says Buse. Because the clinical trials have ended, the participants must now wait for FDA approval to use insulin glargine again.

More Stable

Buse believes that this 24-hour insulin is more stable in its absorption, but cannot precisely explain why.

"With other long-acting insulins, it is a multi-step process to get absorbed in the body," reports Buse. Upon injection, these insulins' crystals first have to break up, then the insulin crosses into the bloodstream. "Each of these steps is affected by a variety of causes."

Insulin glargine, however, dissolves in a different way that doesn't turn it into crystal. "Insulin glargine precipitates inside the body," according to Buse. "It is absorbed more regularly than crystals."

Buse claims that it does not make a difference whether you take your single insulin glargine shot in the morning or evening. It has a "slight peak," he says, about 12 to 14 hours after injection, so that should be taken into account.

Click Here To View Or Post Comments

Categories: Diabetes, Food, Government & Policy, Insulin

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...

Username: Password:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.