Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12 Tips for Traveling With Diabetes
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter
Latest
Popular
Top Rated
Diabetes Archives
Print | Email | Share | Comments (0)

Subjects in Honeymoon Phase Needed in Type 1 Drug Trial

Feb 1, 2000

Saving Beta Cells in Newly Diagnosed Patients

A promising drug trial at the Naomi Berrie Diabetes Center at New York's Columbia Presbyterian Medical Center needs children, aged 8 and older, who have recently been diagnosed with type 1 diabetes, to participate.

In the early stages of type 1 diabetes, the pancreas is still capable of producing insulin, albeit in a diminished capacity. By the end of the honeymoon phase, which can last three to five years, insulin production shuts down. It goes without saying that patients who can continue to produce insulin will fare better than those who cannot. So far, nothing has been successful in reversing type 1 diabetes, especially when it is accompanied by high blood glucose levels.

Lead researcher Kevan Herold, MD, hopes that an immunosuppressive drug called hOKT3gamma1, if administered early in the honeymoon phase, might help to stop or reverse the progression of the disease. hOKT3gamma1 is a genetically modified form of OKT3 which is commonly used to prevent rejection of transplanted organs. Unlike many other immunosuppressive drugs, which indiscriminately attack all immune cells within an area, hOKT3gamma1 only attacks the rogue immune cells responsible for beta cell destruction. In animal studies conducted at the National Institute of Health and Medical Research in Paris, the drug was shown to reverse the progression of diabetes even in the presence of hyperglycemia, and normal blood sugars were restored without the need for insulin.

"We are set to determine whether the drug will alter the natural history of the disease and improve the ability to make insulin over a two-year period," Herold was quoted as saying in the Winter 2000 issue of JDF International Countdown.

Parents who are interested in enrolling their type 1 children in this trial should call 212-304-5492 or email: kh318@columbia.edu.


Categories: Beta Cells, Blood Glucose, Blood Sugar, Diabetes, Insulin, Type 1 Issues, Type 1 Issues



You May Also Be Interested In...


Comments


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...


Username: Password:
Comment:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.