Lilly Offers Pen Mixture with Humalog

May 1, 2000

On March 20, Eli Lilly and Company announced the availability of the first pre-mixed insulin containing the rapid-acting insulin lispro (Humalog). Called the Humalog Mix 75/25 Pen, the mixture combines 75 percent insulin lispro protamine suspension (similar to NPH) and 25 percent insulin lispro injection (rDNA origin).

"Coping with diabetes is a lot like running a marathon and a sprint simultaneously," says John Buse, MD, director of the Diabetes Care Center at the University of North Carolina. "Patients need insulin that will quickly address their meal-time needs, as well as handle the glucose released into their bloodstream throughout the day. In addition, patients need options that will help them stick with their medication."

Humalog Mix75/25 Pen was approved by the U.S. Food and Drug Administration in December 1999. According to Eli Lilly, combining the benefits of a rapid-acting, meal-time insulin and an intermediate-acting insulin provides BG control at meal times, between meals and at night time. Humalog Mix75/25 has a duration of action similar to Humulin 70/30.

Studies show that Humalog is more effective than regular insulin at lowering glucose levels after meals. The clinical significance of improvement in post-meal hyperglycemia with Humalog has not been established. In 12-month clinical studies, HbA1c did not differ with Humalog.

"The Humalog Mix 75/25 Pen is all about making a difficult, complex disease easier to deal with," says Thane Wettig, brand leader of U.S. diabetes care at Lilly. "Patients who want the benefits of Humalog no longer need to mix their own insulins or take two shots at a time. The fact that Humalog Mix75/25 is available in the prefilled pen adds to the convenience."

The Humalog Mix 75/25 Pen is available by prescription only. Potential side effects associated with the use of all insulins include hypoglycemia, weight gain, lipodystrophy and hypersensitivity. Lilly advises that because of the difference in the action of Humalog, patients in whom these conditions may be clinically relevant should take extra care. Also, patients are not advised to mix Humalog Mix 75/25 with another insulin.

For more information, call Eli Lilly at 800-545-5979.

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