New Long-Acting Insulin Approved by the FDA Glargine (Lantus) Provides Concentration Over 24-hour Period

Jun 1, 2000

On April 24, Aventis Pharmaceuticals of Parsippany, New Jersey, announced that the U.S. Food and Drug Administration has approved the 24-hour basal insulin glargine (now called Lantus) for the treatment of type 1 and type 2 diabetes. The company plans to launch the drug in September. Because it lasts for 24 hours, Lantus can be taken once per day. Other insulin products, according to Aventis, only have a 14.5-hour duration and must be administered at least two times per day.

Lantus is also indicated for daily use in kids with type 1 diabetes.

Patients Loved it

In the July 1999 issue of Diabetes Health, John Buse, MD, PhD, CDE, director of the University of North Carolina's Diabetes Center, said people in clinical trials loved Lantus. Buse says most of the people who participated in the clinical trials were not doing well on NPH or Ultralente. Lantus, however, improved their control.

"With other long-acting insulins, it is a multi-step process to get absorbed in the body," said Buse. "Upon injection, these insulins' crystals first have to break up, then the insulin crosses into the bloodstream. Each of these steps is affected by a variety of causes."

Lantus dissolves in a different way. It never turns it into crystal.

"[Lantus] precipitates inside the body," according to Buse. "It is absorbed more regularly than crystals."

Buse claims that it does not make a difference whether you take your single Lantus shot in the morning or evening. It has a "slight peak," he says, about 12 to 14 hours after injection, so that should be taken into account.

Hypoglycemia Most Common Adverse Effect

Aventis says hypoglycemia is the most common adverse effect of insulins, including Lantus. In clinical studies of adult patients, there was a higher incidence of injection site pain (2.7 percent Lantus versus 0.7 percent NPH). The reports of pain at the injection site were usually mild and did not result in discontinuation of therapy.

As with all insulins, the timing of hypoglycemia may differ among various insulin formulations. Glucose monitoring is recommended for all patients with diabetes.

To receive prescribing information, call (800)552-3656, or visit the Aventis Web site at

Click Here To View Or Post Comments

Categories: Diabetes, Diabetes, Food, Insulin, Lantus, Low Blood Sugar, Type 1 Issues, Type 2 Issues

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12th Annual Product Reference Guide
  • Insulin Syringe Chart
  • Insulin Pen Needles Chart
  • Fast-Acting Glucose
  • Sharps Disposal
  • Blood Glucose Meters Chart
  • Insulin Pumps Chart
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...

Username: Password:
©1991-2015 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.