President Clinton Announces 10 New Transplant Sites - Revolutionary New Islet-transplant Procedure to Begin This Fall

| Sep 1, 2000

On July 13, President Clinton announced the 10 centers chosen to replicate the Edmonton Protocol.

The $5 million Edmonton Protocol replication will begin this fall and will be overseen by the Immune Tolerance Network (ITN), a research program jointly funded by the National Institutes of Health (NIH) and the Juvenile Diabetes Foundation (JDF). As part of the replication, approximately 40 patients will receive islet transplants in the next 18 months through the ITN clinical trials.

"This is an important moment for people with diabetes," said Mary Tyler Moore, international chairman of the JDF. "We greatly applaud the Administration's commitment to diabetes research and are proud to partner with the NIH on replicating the Edmonton Protocol for human islet transplantation through the Immune Tolerance Network."

Bringing the Cure Closer to Home

James Shapiro, MBBS, BMed, a transplant surgeon for the Edmonton Protocol team, told DIABETES HEALTH he is pleased with the announcement.

"I am thrilled that the proposed study, together with the preliminary extraordinary results from the Edmonton Protocol, was considered important enough to gain the attention of the U.S. President," said Shapiro. "I'd be even more thrilled if the overall results of the multi-center study match up to the success we have seen in Edmonton. This will bring islet transplantation as a cure so much closer to all patients with diabetes."

10 People Off Insulin After One Year

The Edmonton Protocol research team recently published its findings in The New England Journal of Medicine. Shapiro and colleagues at the University of Alberta in Edmonton transplanted islets in 10 people with type 1 diabetes. In previous studies, only eight percent of islet-transplant recipients have remained off insulin for one year.

The Edmonton Protocol is the first study in which 100 percent of islet-transplant recipients were completely insulin-independent after one year. The keys to the success of the Edmonton Protocol are a new anti-rejection drug combination, the avoidance of steroids and the delivery of sufficient islets.


According to the JDF, only "brittle" type 1 diabetes patients, ranging from 18 to 65 years of age, who are unable to properly control their sugars with even the most rigid insulin schedule, are eligible to participate. Patients must also suffer from one of the following:

  • hypoglycemia unawareness
  • at least one hypoglycemic reaction in the last 1.6 years that cannot be otherwise explained and required medical attention
  • progressive secondary complications, such as vision, kidney, nerve or vascular problems, despite an optimal insulin regime
  • failure of intensive insulin management, as judged by an independent endocrinologist

People with type 2 diabetes and children are not eligible for enrollment in the trial. In addition, type 1s with severe cardiac disease, active or recent history of substance abuse (including smoking), insulin requirements greater than 0.7 U/kg per day or active infection (including hepatitis B or C, HIV or TB) are not eligible to participate.

U.S. residents who meet the requirements who are interested in participating are asked to visit the ITN Web site at or call the ITN Patient Referral Hotline at (773) 834-5341.

Click Here To View Or Post Comments

Categories: Diabetes, Diabetes, Government & Policy, Insulin, Islet & Pancreas Transplant, Low Blood Sugar, The Cure, Type 1 Issues, Type 2 Issues

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12th Annual Product Reference Guide
  • Insulin Syringe Chart
  • Insulin Pen Needles Chart
  • Fast-Acting Glucose
  • Sharps Disposal
  • Blood Glucose Meters Chart
  • Insulin Pumps Chart
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...

Username: Password:
©1991-2015 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.