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Neuropathy Be Gone! Gabapentin Provides Greater Pain Relief and Less Side Effects Than Amitriptyline
After conducting a 12-week trial, Italian researchers have concluded that gabapentin provides greater pain relief for diabetic neuropathy than amitriptyline, without causing as many adverse effects.
The researcher's observations were published in the October 2000 issue of the Journal of Pain and Symptom Management. Recent research has demonstrated the effectiveness and safety of gabapentin for the treatment of painful diabetic neuropathy.
For the 12-week trial, 13 patients were randomized to receive gabapentin and 12 were treated with amitriptyline. The gabapentin dose began at 400 mg per day and was titrated up to 2400 mg per day over four weeks. During the same time frame, amitriptyline began at 10 mg per day and was titrated up to 90 mg per day.
A similar number of patients in each group achieved a pain score of one or less, but in three patients taking gabapentin pain was completely eliminated. Nobody taking amitriptyline achieved this level of pain reduction.
Adverse effects were less common in the gabapentin group than in the amitriptyline group, occurring in four and 11 patients, respectively.
Categories: Diabetes, Diabetes, Nerve Care (Neuropathy)
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Feb 1, 2001
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Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
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