Putting on the Breaks

Glucophage Might Slow Down Weight Gain and Insulin Resistance in Obese Kids

| Jun 1, 2001

Because of the obesity epidemic in this country, the disease formerly called "adult-onset" diabetes is no longer given that label. Type 2 diabetes, we have learned, is fair game for people of all ages.

For adolescents with type 2 diabetes, a popular type 2 drug may interrupt the cycle of weight gain and insulin resistance that leads to the disease.

According to the April issue of Pediatrics, researchers at the departments of Pediatrics and Cell Biology at Duke University in Durham, North Carolina say Glucophage, manufactured by Bristol-Myers Squibb, might "complement the effects of dietary and exercise counseling and reduce the risk of type 2 diabetes in selected patients."

Glucophage, which works by making the body more responsive to insulin, was used in a study that consisted of 29 white and black adolescents ages 12 to 19 years. All adolescents in the study had a body mass index of 30 or greater, meaning that they were considered very overweight. Patients received either Glucophage in 500-mg doses twice daily or a placebo for six months.

The Glucophage group, it was discovered, had a 1.3 percent decline in body mass index, while the placebo group showed an increase of 2.3 percent. In addition, Glucophage caused a decline in fasting blood glucose from an average of 84.9 mg/dl to 75.1 mg/dl. The placebo group showed a fasting blood glucose increase from 77.2 mg/dl to 82.3 mg/dl. Also, insulin sensitivity increased in the Glucophage-treated group.

HbA1c was not affected in either the Glucophage or placebo group.

Glucophage caused diarrhea in 40 percent of the treated participants; however, there were no episodes of vomiting or lactic acidosis.

The authors of the study have called for further research.

Click Here To View Or Post Comments

Categories: A1c Test, Adolescent Boys, Adolescent Girls, Blood Glucose, Diabetes, Diabetes, Insulin, Kids & Teens, Research, Type 2 Issues

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12th Annual Product Reference Guide
  • Insulin Syringe Chart
  • Insulin Pen Needles Chart
  • Fast-Acting Glucose
  • Sharps Disposal
  • Blood Glucose Meters Chart
  • Insulin Pumps Chart
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...

Username: Password:
©1991-2015 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.