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New Insulin Under Development
Preparation May Be Better for After-Meal Control
Stephen N. Davis, MD
A new insulin preparation reduces after-meal blood-glucose (BG) values in people with diabetes without causing hypoglycemia.
Calling the new preparation hepatic directed vesicle-insulin (HDV-insulin), researchers at Vanderbilt University are suggesting it may "prove to be more suitable than Regular insulin for aggressive therapy," according to a September 28 Reuters Health report.
In the September/October issue of the Journal of Diabetes and Its Complications, Stephen N. Davis, MD, and colleagues call the advantages of HDV-insulin "two-fold," saying that insulin directed at the liver should suppress the output of glucose by that organ while increasing its ability to metabolize glucose. Also, they said, improved post-meal blood-glucose levels can be obtained with reduced insulin circulating in the bloodstream.
The investigators note that adding a molecule that targets the liver to a soluble pouch designed to deliver insulin created HPV-insulin. According to Reuters, the effects of a single injection of HDV-insulin or Regular insulin administered 30 minutes before a 75-gram oral glucose tolerance test in nine patients with type 1 diabetes were observed. Each subject received the opposite type of insulin in an identical protocol four weeks later.
HDV-insulin lowered glucose levels 39.6 mg/dl during the test compared with Regular insulin.
"Plasma levels of insulin and glucagon were equivalent during both series of experiments," according to the paper.
Categories: Diabetes, Diabetes, Health Insurance, Insulin, Low Blood Sugar, Type 1 Issues
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Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
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