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A 37-year-old woman with type 1 diabetes who was pregnant with her second child was able to eliminate frequent severe hypoglycemic episodes after being switched from NPH insulin to Lantus (insulin glargine), report two doctors and a nurse practitioner in a letter to Diabetes Care.
The woman had required emergency injections of glucagon as frequently as three times a week before being switched to Lantus. After the NPH was discontinued and Lantus substituted in her 14th week of pregnancy, the severe hypoglycemic episodes stopped, although her control remained excellent, with A1Cs less than 6%.
Lantus has not been approved in the United States for use during pregnancy. However, the authors note that overnight hypoglycemia "may be a significant clinical problem" during pregnancy because of the lower recommended glycemic targets during that time. They suggest that such nighttime hypoglycemia may be less common with evening injections of Lantus.
—Diabetes Care, June 2002