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A shift in fat distribution from visceral (the internal abdominal area) to subcutaneous (under the skin) could be the reason the insulin sensitizer Actos (pioglitazone) helps to lower blood glucose levels in people with insulin resistance.
Despite an average weight gain of nearly 7 pounds and an increase in total fat mass during that time, fasting blood glucose levels fell from an average of 179 mg/dl to 140 mg/dl, and A1C levels dropped from 8.6% to 7.2%. Fat distribution was evaluated with magnetic resonance imaging (MRI), which showed a decreased ratio of visceral to subcutaneous fat during the study.
-Journal of Clinical Endocrinology & Metabolism, June 2002
0 comments - Nov 1, 2002
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.