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Weighing the Evidence
Blood-Glucose Levels Decrease With Insulin Sensitizer Despite Weight Increase
A shift in fat distribution from visceral (the internal abdominal area) to subcutaneous (under the skin) could be the reason the insulin sensitizer Actos (pioglitazone) helps to lower blood-glucose levels in people with insulin resistance.
Researchers from the University of Texas studied nine people with type 2 diabetes who took Actos for 16 weeks.
Despite an average weight gain of nearly 7 pounds and an increase in total fat mass during that time, fasting blood-glucose levels fell from an average of 179 mg/dl to 140 mg/dl, and A1C levels dropped from 8.6% to 7.2%. Fat distribution was evaluated with magnetic resonance imaging (MRI), which showed a decreased ratio of visceral to subcutaneous fat during the study.
—Journal of Clinical Endocrinology & Metabolism, June 2002
Categories: A1c Test, Actos, Diabetes, Diabetes, Insulin, Type 2 Issues, Weight Loss
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Nov 1, 2002
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Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
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