Home
You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View
See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.
Latest Insulin Articles
Popular Insulin Articles
Highly Recommended Insulin Articles
Email to a Friend
Send a link to this page to your friends and colleagues.
Prandin Versus Glucophage
Which Provides Better Control
When combined with NPH insulin taken at bedtime, Glucophage (metformin) provides slightly better glucose control with less weight gain and improved satisfaction with diabetes treatment than Prandin (repaglinide) plus NPH, say researchers in the United Kingdom.
Eighty subjects with type 2 diabetes who took both Glucophage and nighttime NPH insulin were randomly assigned either to 13 weeks of treatment with 4 mg of Prandin taken twice a day or to treatment with their usual dose of Glucophage. In both groups, insulin doses were adjusted to aim for a fasting blood-glucose level of 108 mg/dl.
Blood-glucose control improved marginally in the group that took Glucophage plus bedtime insulin, with a corresponding 0.45 percent drop in A1C levels, from an average of 8.4% to 8.1%. A1C levels deteriorated in the group that took Prandin along with bedtime insulin, increasing 0.4 percent, from an average of 8.1% to 8.6%. Those on Glucophage gained an average of about 2 pounds, whereas the group that took Prandin gained nearly 6 pounds on average. Frequency of hypoglycemia was similar for both treatments, and all episodes were mild and self-treated.
On a scale of 0 to 36, diabetes treatment satisfaction rose from 32.4 to 34.1 in the Glucophage group and decreased from 32.5 to 29.1 in the Prandin group.
—Diabetes Care, October 2002
Categories: A1c Test, Diabetes, Diabetes, Insulin, Low Blood Sugar, Type 2 Issues, Type 2 Medications
You May Also Be Interested In...
-
Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
-
Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
Comments
Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.
When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.
For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.
Don't have your Diabetes Health Username? Register now and add your comments to all our content.
Register...
Register your Diabetes Health Username here.
Have Your Say...