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The U.S. Food and Drug Administration has approved a new indication for Glucovance (glyburide and metformin tablets), allowing the type 2 diabetes medication to be taken in combination with thiazolidinediones (TZDs) when adequate control is not achieved with diet and exercise.
According to an October 11, 2002, news release from Bristol-Myers Squibb (BMS), the drug's manufacturer, clinical studies report that 42 percent of people with type 2 diabetes taking Glucovance with Avandia (rosiglitazone) achieved an A1C level of 7% or less.
BMS cautions that, in rare cases, Glucovance can cause lactic acidosis (a buildup of lactic acid in the blood), which can be fatal. People should not take Glucovance if they have kidney problems; if they are over 80 years of age (unless their kidneys have been tested); if they are taking medication for heart failure; or if they are seriously dehydrated, have a serious infection or have had liver disease. The most common side effect is diarrhea. People should not take Avandia or other TZDs unless laboratory tests show normal liver function.