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In a small study involving 22 people with diabetes (20 with type 2, all with painful neuropathy), researchers in the United Kingdom compared the effects of isosorbide dinitrate (ISDN) spray—sold in the United States under the brand names Isordil and Sorbitrate—to a spray that contained no active ingredients. Half the subjects used the ISDN spray for four weeks, while the other half used the placebo.
After a two-week period during which no sprays were used, the groups exchanged treatments.
Following the study, half of the subjects reported that their neuropathy pain was lessened and opted to continue using the spray on their feet. Of the remaining 11 people, four preferred the placebo spray and seven were undecided.
The researchers note that they chose ISDN for this pilot study based on considerable evidence that impaired nitic oxide generation is involved in diabetes-related neuropathy pain. ISDN is a drug that donates nitric oxide and helps to improve circulation.
—Diabetes Care, October 2002
0 comments - Feb 1, 2003
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.