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Babies Sought for Diabetes Prevention Study
A multinational 10-year study, known as the Trial to Reduce Insulin-Dependent Diabetes in the Genetically at Risk (TRIGR), is enlisting the participation of newborns who have a parent or sibling with type 1 diabetes.
TRIGR is the first diabetes trial that will assess the relationship of infant formula consumption to the likelihood of developing type 1 diabetes in genetically susceptible infants. Its results could lead to early interventions, before babies develop antibodies that signal the beginning of an autoimmune attack that destroys the insulin-creating islet cells in the pancreas.
The study, which encourages and emphasizes breast-feeding, will compare several groups of breast-fed babies. When the babies are weaned, or if an infant needs supplementation, the diet of one group will be supplemented with a study formula called Nutramigen, a hydrolyzed cow's milk-based formula, in which the protein casein is broken down into smaller molecules, which are likely to be too small to stimulate the immune system. Another group of infants will supplement with Enfamil, a standard cow's milk-based formula (not hydrolyzed).
Researchers in Canada have shown that hydrolyzed cow's milk formula reduces the incidence of type 1 diabetes in diabetes-prone rats and mice by as much as 80 to 90 percent. They speculate that the absence of intact protein in the formula may be the reason.
If you are interested in having your baby participate in the TRIGR study, contact Peggy Franciscus, RN, at (412) 692-5250 or by e-mail at m_franciscus @yahoo.com, before or immediately after the baby's birth. For more information on the TRIGR study, log on to www.trigr.org.
The following U.S. sites are involved in the study:
St. Louis, Missouri
- St. Louis Children's Hospital
- Washington University
Seattle, Washington
- University of Washington
New York, New York
- Naomi Berrie Diabetes Center at Columbia-Presbyterian Medical Center
- Columbia University
Los Angeles, California
- Mattel Children's Hospital, Divisions of General Pediatrics and Neonatology
- University of Southern California
Pittsburgh, Pennsylvania
- Children's Hospital of Pittsburgh
- University of Pittsburgh
Puerto Rico
- San Luis Hospital
- Ponce University
Categories: Diabetes, Diabetes, Insulin, Kids & Teens, Support Groups, Type 1 Issues, Type 1 Issues
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Feb 1, 2003
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Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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