Glyburide/Metformin Combination Tablet Delivers Surprising Results

| Mar 1, 2004

Who would have guessed that taking two diabetes drugs combined in one tablet would offer greater glucose-lowering benefits than taking the same two drugs in separate but still co-administered tablets?

A glyburide/metformin tablet, marketed in the United States as Glucovance, delivered a significantly greater reduction in A1C than a prior regimen of glyburide co-administered with metformin.

According to a study from Bristol-Myers Squibb and the Ochsner Clinic Foundation in New Orleans, the effect was especially significant when a patient’s baseline A1C level was 8%.

The therapy was tested in 950 patients—471 of whom received glyburide co-administered with metformin. The average A1C decrease for the combination tablet group was 2.02%, compared with a decrease of 1.49% for glyburide co-administered with metformin, despite the fact that the patients receiving the combination tablet received lower doses of the medications.

The study data were obtained from retrospective pharmacy claims data and corresponding laboratory results from a usual-care setting.

Diabetes, Obesity and Metabolism, November 2003

Click Here To View Or Post Comments

Categories: A1c Test, Diabetes, Diabetes, Metformin, Type 2 Medications

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12th Annual Product Reference Guide
  • Insulin Syringe Chart
  • Insulin Pen Needles Chart
  • Fast-Acting Glucose
  • Sharps Disposal
  • Blood Glucose Meters Chart
  • Insulin Pumps Chart
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...

Click Here To View Or Post Comments

Comments 0 comments - Mar 1, 2004

©1991-2015 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.