Risks and Benefits of Islet Transplantation

A Report From the NIH’S Islet Transplant Center

| Apr 1, 2004

Islet transplantation offers promise, but it still shows risks of complications and loss of islet function over time.

After initiating a new islet isolation and transplant center, National Institutes of Health researchers related their experiences, sharing the islet transplant outcomes of six female type 1s, all with a history of hypoglycemia unawareness and no self-production of insulin (serum C-peptide negative).

These patients received the antirejection drugs daclizumab, sirolimus and tacrolimus-a steroid-sparing combination.

Results showed that all patients noted less frequent and less severe low blood glucose episodes, and 50 percent were insulin-free at one year after transplant. All but one showed serum C-peptide levels indicating continued islet cell insulin-production function.

Two major complications were serious intra-abdominal bleeding and partial portal vein thrombosis (blockage by blood clotting). In addition, recipients frequently developed transient mouth ulcers, diarrhea, edema (fluid retention), high blood cholesterol, weight loss, bone-marrow suppression and other symptoms.

Of the six patients, three discontinued the anti-rejection drugs, two because of intolerable toxicity, such as decreasing kidney function, while still showing islet function, and one because of loss of islet function.

-Diabetes Care, December 2003

Click Here To View Or Post Comments

Categories: Blood Glucose, Diabetes, Diabetes, Hypoglycemia Unawareness, Insulin, Islet & Pancreas Transplant, Low Blood Sugar, Type 1 Issues

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12th Annual Product Reference Guide
  • Insulin Syringe Chart
  • Insulin Pen Needles Chart
  • Fast-Acting Glucose
  • Sharps Disposal
  • Blood Glucose Meters Chart
  • Insulin Pumps Chart
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...

Click Here To View Or Post Comments

Comments 0 comments - Apr 1, 2004

©1991-2015 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.