Home
You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View
See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.
Latest Hypoglycemia Unawareness Articles
Popular Hypoglycemia Unawareness Articles
Highly Recommended Hypoglycemia Unawareness Articles
Risks and Benefits of Islet Transplantation
A Report From the NIH’S Islet Transplant Center
Islet transplantation offers promise, but it still shows risks of complications and loss of islet function over time.
After initiating a new islet isolation and transplant center, National Institutes of Health researchers related their experiences, sharing the islet transplant outcomes of six female type 1s, all with a history of hypoglycemia unawareness and no self-production of insulin (serum C-peptide negative).
These patients received the antirejection drugs daclizumab, sirolimus and tacrolimus-a steroid-sparing combination.
Results showed that all patients noted less frequent and less severe low blood glucose episodes, and 50 percent were insulin-free at one year after transplant. All but one showed serum C-peptide levels indicating continued islet cell insulin-production function.
Two major complications were serious intra-abdominal bleeding and partial portal vein thrombosis (blockage by blood clotting). In addition, recipients frequently developed transient mouth ulcers, diarrhea, edema (fluid retention), high blood cholesterol, weight loss, bone-marrow suppression and other symptoms.
Of the six patients, three discontinued the anti-rejection drugs, two because of intolerable toxicity, such as decreasing kidney function, while still showing islet function, and one because of loss of islet function.
-Diabetes Care, December 2003
Categories: Blood Glucose, Diabetes, Diabetes, Hypoglycemia Unawareness, Insulin, Islet & Pancreas Transplant, Low Blood Sugar, Type 1 Issues
You May Also Be Interested In...
Click Here To View Or Post Comments
0 comments -
Apr 1, 2004
-
Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
-
Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
Email to a Friend
Send a link to this page to your friends and colleagues.