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Immunization by Skin Patch May Pose Problem
Applying vaccinations to the skin might actually be harmful to some individuals, according to Australian researchers.
Because the skin is an essential organ—providing both a barrier for the body’s defense and a source of immunity—this study explored the safety and efficacy of using the skin as a method of immunization compared to using the nose or mouth. Applying bacterial products to the skin as an alternate route of administering immunizations against infectious disease could precipitate autoimmune diseases in those genetically at risk.
In the study, researchers applied cholera toxin to intact mouse skin and found that autoimmune diseases were induced or enhanced in distant organs. However, when the toxin was ingested through the nose or mouth, it was reported to have the opposite effect.
When cholera toxin was applied to the skin alone or in combination with insulin, there was an increase in the rate and onset of type 1 diabetes in genetically susceptible mice.
-Diabetes Care, March 2004
Categories: Diabetes, Diabetes, Insulin, Type 1 Issues, Type 1 Issues
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May 1, 2004
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Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
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