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Baseline A1C Level Is the Key
Rapid-Acting Insulin Delivery—Pumps or Multiple Injections?
In people with higher A1Cs, rapid-acting insulin analogs NovoLog (insulin aspart) and Humalog (insulin lispro) are more effective in achieving optimal blood glucose control when administered with insulin pumps rather than via multiple daily insulin injections (MDII), according to University of Toronto researchers.
Data on 139 adults with type 1 diabetes were evaluated from previous studies. The studies differed significantly in mean baseline A1C levels (7.95%, 8.20% and 9.27%).
“A model derived from these data predicts that in a patient with a baseline A1C of 10%, [rapid-acting insulin in pumps] would reduce the A1C by an additional 0.65% compared with MDII,” write the researchers. On the other hand, there would be no A1C benefit to using rapid-acting insulin in pumps, compared with MDII, if baseline A1Cs were 6.5%.
The researchers conclude that using fast-acting insulin in pumps may be uniquely advantageous in adults with type 1 diabetes and poor blood glucose control.
Categories: A1c Test, Blood Glucose, Diabetes, Diabetes, Insulin, Type 1 Issues
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Jan 1, 2005
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Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
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