Salmonella Infection Halts Type 1 Development in NOD Mice


| Feb 1, 2005

Could infecting someone with Salmonella possibly ward off the onset of type 1 diabetes?

We may never know, because replicating a recent study of nonobese diabetic (NOD) mice in humans would require nondiabetic individuals to infect themselves.

“Infectious disease has been proposed as an environmental modifier of autoimmunity in both human populations and the NOD mouse,” write researchers in the United Kingdom. “We found that infection of NOD mice with attenuated—but not killed—Salmonella typhimurium can reduce the incidence of type 1 diabetes in NOD mice.”

European Journal of Immunology

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