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Contrary to recent reports claiming that embryonic stem cells can generate insulin-producing cells, a Scandinavian study has found that this is not the case.
Although differentiated insulin-containing cells contain immunoreactive insulin, they do not contain proinsulin-derived C-peptide. There is variable insulin release from these cells upon glucose addition, but C-peptide release is never detected. Also, many of the insulin-immunoreactive cells are disintegrating or dying.
The study indicates that C-peptide biosynthesis and secretion should be demonstrated to claim insulin production from embryonic stem cell progeny.
—Diabetes, October 2004
Feb 1, 2005
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