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Contrary to recent reports claiming that embryonic stem cells can generate insulin-producing cells, a Scandinavian study has found that this is not the case.
Although differentiated insulin-containing cells contain immunoreactive insulin, they do not contain proinsulin-derived C-peptide. There is variable insulin release from these cells upon glucose addition, but C-peptide release is never detected. Also, many of the insulin-immunoreactive cells are disintegrating or dying.
The study indicates that C-peptide biosynthesis and secretion should be demonstrated to claim insulin production from embryonic stem cell progeny.
—Diabetes, October 2004
Feb 1, 2005
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.