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Islet & Pancreas Transplant Archives
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Insulin Release in Embryonic Stem Cells


Feb 1, 2005

New Study Disputes Claims

Contrary to recent reports claiming that embryonic stem cells can generate insulin-producing cells, a Scandinavian study has found that this is not the case.

Although differentiated insulin-containing cells contain immunoreactive insulin, they do not contain proinsulin-derived C-peptide. There is variable insulin release from these cells upon glucose addition, but C-peptide release is never detected. Also, many of the insulin-immunoreactive cells are disintegrating or dying.

The study indicates that C-peptide biosynthesis and secretion should be demonstrated to claim insulin production from embryonic stem cell progeny.

Diabetes, October 2004


Categories: Diabetes, Diabetes, Insulin, Islet & Pancreas Transplant



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