Use of Metformin May Decrease Cancer Risk

| Aug 1, 2005

Metformin activates the enzyme AMPK (AMP-activated protein kinase), which promotes muscles to take up glucose from the blood. It was recently discovered that the upstream regulator of AMPK is a protein kinase called LKB1, known to be a tumor suppressor.

Therefore, researchers in Scotland suggest that metformin use in patients with type 2 diabetes may reduce their risk of cancer.

Using various databases to conduct this case-control, observational study, medical records of more than 300,000 patients were analyzed. Approximately 12,000 of these patients were newly diagnosed with type 2 diabetes between 1993 and 2001, including 923 who were later diagnosed with cancer.

Information about metformin use for all cases and controls was calculated, with odds ratios adjusted for factors such as body mass index, blood pressure and smoking. During the year prior to diagnosis of cancer, 36.4 percent of cases and 39.7 percent of controls had been prescribed metformin. A dose-response relationship between metformin use and cancer was observed, indicating a decreased risk of cancer with longer duration of metformin treatment and total dosage.

The researchers note limitations to the findings of this pilot study and state they are planning a large cohort study to further explore the relationship of metformin use in diabetics and the possible decreased risk of cancer. The new study will focus on specific types of cancer and use more precise dates of cancer diagnosis.

British Medical Journal, April 22, 2005

Click Here To View Or Post Comments

Categories: Diabetes, Diabetes, International, Metformin, Research, Type 2 Issues, Type 2 Medications


Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Latest
Popular
Top Rated
Print | Email | Share | Comments (1)

You May Also Be Interested In...


Comments

Posted by Anonymous on 1 March 2009

Why make it so difficult? It may be due to the LBK1, but more obviously it may be that the cancer cells starve do death, because it depends on glukose or glukoneogenesis to survive.

Why do we never hear about the basic properties of cancer cells? High sugar consumption, low oxygen and low pH (lactic acid). I think it's because the simple and best way are not the most pofitable.


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...


Username: Password:
Comment:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.