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Overweight type 1s may improve their blood glucose control without increasing their insulin dosage by supplementing their control regimen with the type 2 insulin-sensitizing drug Avandia (rosiglitazone), say Dallas, Texas, researchers.
A total of 50 adult type 1s with a body mass index of 27 were randomly assigned to take insulin and placebo or insulin and 4 milligrams of Avandia twice daily for a period of eight months. The treatment goal in both groups was to achieve near-normal glucose levels.
A1C levels in both groups improved significantly. The total daily insulin dose decreased slightly in subjects taking Avandia an average of 77.5 to 75.3 units.
The incidence of weight gain and of hypoglycemia did not differ between the two treatment groups.
—Diabetes Care, July 2005
Sep 1, 2005