ACTOplus Met Approved by the FDA for Type 2 Diabetes

New product combines two widely used diabetes medications in a single tablet

| Nov 1, 2005

In August 2005, Takeda Pharmaceuticals North America, Inc., announced that the U.S. Food and Drug Administration (FDA) had approved ACTOplus Met for the treatment of type 2 diabetes.

The new medication combines the two popular type 2 drugs Actos (pioglitazone HCl) and metformin HCl, providing convenience to patients.

ACTOplus met will be available in two dosages of pioglitazone with metformin: 15 mg/500 mg and 15 mg/850 mg. The medication is taken once a day or in divided doses.

Side Effects

According to Takeda, a small number of people who have taken metformin, a component of ACTOplus met, have developed a rare but serious condition called lactic acidosis—a buildup of lactic acid in the blood, which can be fatal in about half of cases. ACTOplus met should not be used in people with kidney disease or in people 80 years of age and older who have any problems with kidney function.

Actos and ACTOplus met can cause fluid retention (swelling) that may lead to or worsen heart failure. Talk to your doctor immediately if you experience rapid weight gain, fluid retention or shortness of breath while taking either drug.

Your health professional should perform a blood test to check for liver problems before you start Actos or ACTOplus met and periodically thereafter. Do not take Actos or ACTOplus met if you have active liver disease.

You should also talk to your doctor immediately if you experience nausea, vomiting, stomach pain, tiredness, loss of appetite, dark urine or yellowing of the skin.

For more information, log on to

* * *

Source: Takeda Pharmaceuticals

Click Here To View Or Post Comments

Categories: Actos, Diabetes, Diabetes, Food, Government & Policy, Medications, Metformin, Type 2 Issues, Type 2 Medications

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12th Annual Product Reference Guide
  • Insulin Syringe Chart
  • Insulin Pen Needles Chart
  • Fast-Acting Glucose
  • Sharps Disposal
  • Blood Glucose Meters Chart
  • Insulin Pumps Chart
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...

Click Here To View Or Post Comments

Comments 0 comments - Nov 1, 2005

©1991-2015 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.