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Japanese researchers replicating the research of Denise Faustman, MD, have noted that islets increased in size in “reversed” non-obese diabetic mice after a pancreatic beta cell transplant.
“In this study, we aimed to “reverse” hyperglycemic state to normoglycemic state in autoimmune diabetic mice,” write the researchers. “Since beta cells are destructed by effector cells, at least . . . two factors are necessary when “reversing” hyperglycemia in autoimmune diabetes: depletion of effector cells and enhancement of beta-cell regeneration.”
The researchers attempted to send the type 1 mice into remission by combining CFA (complete Freund’s adjuvant) administration and transplanted beta cells.
Type 1 mice between the ages of 18 to 40 weeks of age with recent onset of type 1 were injected with the adjuvant and beta cell combination.
“Five out of seven mice [71 percent] receiving [beta cells and CFA] achieved normoglycemia by 120 days post-treatment,” write the researchers.
Histological examination of pancreases from “reversed” mice showed a decrease in the number of islets, but each of the islets was markedly bigger.
“The size of the islets in ‘reversed’ mice was five to 10 times larger than that in control mice,” write the researchers. “The mechanism of inducing remission is unclear at this moment, but this methodology will give us a clue of a novel therapy for type 1 diabetes.”
Sep 1, 2006
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