Type 2 Research

From the ADA Scientific Sessions

Sep 1, 2006

Reducing Inner Body Fat Is the Key to Metabolic Improvement After Weight Loss

Reducing visceral fat (the fat that surrounds the body’s vital organs) is responsible for metabolic improvements after weight loss, say Italian researchers. Reduction in subcutaneous fat (fat under the surface of the skin) is not, however.

“In 10 obese subjects, we determined visceral and subcutaneous abdominal fat volume by MRI [magnetic resonance imaging],” they write. “Subjects were then enrolled in a weight-reduction program based on dietary and lifestyle counseling, and MRI was repeated after each subject had achieved a weight loss equal to at least 5 percent of the original body weight.”

The researchers observed “a significant correlation between the amount of visceral fat lost and the improvement in insulin sensitivity.” No correlation, however, was observed between the amount or the percentage of subcutaneous fat lost.


Studies Confirm Byetta Efficacy and Safety

Allen B. King, MD, and colleagues undertook a study of the first 100 patients to take Byetta.

The patients’ charts were reviewed. Byetta was initiated at 5 mcg twice a day and increased to 10 mcg twice a day within four weeks in most cases. Patients were encouraged to reduce their intake of food and to increase activity.

Of the 68 who were still on Byetta at the 12-week mark, King noted that Byetta reduced A1C while allowing a reduction of diabetic medications.


In another Byetta study, German researchers studied the safety and effects of a once-weekly long-acting release formulation of Byetta over the course of 15 weeks in people with type 2.

Forty-five participants were enrolled in a randomized, double-blind, placebo-controlled study. Once-weekly doses of either 0.8 mg or 2.0 mg of long-acting release formulation Byetta or placebo were administered for 15 weeks.

“Exenatide [long-acting release] 0.8 mg and 2.0 mg treatment resulted in reductions from baseline A1C and fasting plasma glucose [42.7 mg/dl and 39 mg/dl, respectively] compared to corresponding increases . . . with placebo,” write the researchers. “With [Byetta] the proportion of patients achieving an A1C [of 7% or less] was 33 percent and 86 percent with 0.8 mg and 2.0 mg long-acting release formulation and 0 percent with placebo.

The researchers note that mild nausea was the most frequent adverse event during treatment with Byetta long-acting release.

No severe hypoglycemia was observed.


Type 2s Should Keep an Eye on Those AGEs

Chinese researchers say that advanced glycation end products (AGEs) play a role in HDL dysfunction in people with type 2. AGEs have been previously implicated in oxidative stress; therefore, the researchers say that increased AGEs may be associated with HDL (“good cholesterol”) dysfunction.

“The association between serum AGEs and the impaired antioxidative activity of HDL suggests that HDL dysfunction in diabetes may be partly due to the increased oxidative stress induced by AGEs,” the researchers conclude. “Whether the reduced antioxidative activity of HDL is due to consumption of HDL-associated antioxidative enzymes and the roles of AGEs involved are under investigation.”


Click Here To View Or Post Comments

Categories: A1c Test, Diabetes, Diabetes, Food, Insulin, Low Blood Sugar, Type 2 Issues, Type 2 Medications, Weight Loss

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12th Annual Product Reference Guide
  • Insulin Syringe Chart
  • Insulin Pen Needles Chart
  • Fast-Acting Glucose
  • Sharps Disposal
  • Blood Glucose Meters Chart
  • Insulin Pumps Chart
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (0)

You May Also Be Interested In...


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...

Username: Password:
©1991-2015 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.