Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12 Tips for Traveling With Diabetes
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter
Latest
Popular
Top Rated
Diabetes Health Reference Charts
Food News Archives
Print | Email | Share | Comments (0)

Trick the Body into Starving on a Plentiful Diet?


Mar 15, 2007

Researchers from Penn State, published in the February 7, 2007 Cell Metabolism, have discovered that when mice are deprived of only a single amino acid, their metabolisms are fooled into thinking they are starving. In response, they stop synthesizing new fats and they use up all their fat stores, losing 97 percent of their body fat in the process.

The researchers found that a certain enzyme, called GCN2 eIF2a kinase, is the critical player that kicks the body into starvation mode. It does this by monitoring deficiencies in amino acids. Removal of just a single amino acid, leucine, from the diet of the mice was sufficient to trigger GCN2 to start a starvation response. Despite the fact that the mice were consuming normal amounts of carbohydrates and fats, they shut down fat synthesis in the liver and mobilized their stored fat deposits. Their bodies were literally tricked into starvation mode by the fact that leucine was missing from the diet.

After 17 days of a leucine-deficient diet, the mice lost 48 percent of their liver mass and 97 percent of the adipose or fatty tissue from their abdomens. The response was very similar to what happens during starvation. In contrast, control mice bred to be missing the GCN2 kinase enzyme kept a steady liver mass and lost only 69 percent of the adipose tissue on their abdomens.


Categories: Food News



You May Also Be Interested In...


Comments


Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...


Username: Password:
Comment:
©1991-2014 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.