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The Cochrane Library recently conducted a review of studies to see if NPH is as good as Lantus and Levemir when used as a basal insulin for people with type 2 diabetes. Six studies comparing insulin glargine (Lantus) to NPH (Neutral Protamine Hagedorn) were examined, as well as two studies comparing insulin detemir (Levemir) to NPH.
Duration of the studies, all of which were rated "low" in methodological quality, ranged from 24 to 52 weeks.
The folks at Cochrane concluded that Lantus and Levemir are almost identical to NPH in lowering A1c's, although Lantus and Levemir are associated with slightly fewer hypoglycemic episodes at night during sleep.
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