Red Wine Ingredient Ups Insulin Sensitivity

Dec 17, 2007

Low doses of resveratrol, an ingredient found in red wine, make insulin-resistant mice more sensitive to insulin. Don't try this at home, however, because you'd have to drink almost a gallon of wine every day to get the same effect.

The study, by Chinese researchers, showed that resveratrol activates SIRT1, an enzyme that has already been linked to longevity, DNA repair, and insulin secretion. SIRT1 suppresses the activity of PTP1B, a molecule that decreases insulin activity.

Initially, SIRT1 levels were low in the cells of the insulin-resistant test mice. Then the mice were given 2.5 mg/ kg/day of resveratrol. The resveratrol increased SIRT1 activity, and the SIRT1 then suppressed the action of PTP1B, leading to an increase in insulin sensitivity even in mice on a high fat diet.

The researchers hope that in the future, resveratrol can be used to prevent or treat insulin resistance in humans. It'd be nice if they could just spike some good red wine with a little extra resveratrol. We'll be waiting.

Sources: EurekAlert; Medline Plus; Cell Metabolism, October 2007

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Categories: Insulin, Nutrition Research, Professional Issues

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Posted by Anonymous on 18 December 2007

ConsumerLab recently tested the leading resveratrol brands and found that many did not contain the amount stated on their labels. The worst was Life Extension, with only 26% of the claimed resveratrol, and the best were Biotivia, Transmax and Bioforte, with 500mg or a bit more than they claimed. The full report is on the ConsumerLab web site.

Posted by Ladybird on 22 December 2007

I understand that peanut butter also contains
resveratrol but have no idea how much in comparison to red wine. I wonder if the Diabetes Health Editor or any other readers have any information on this. I happen to be regular peanut butter eater, love it AND it's very good for people who want to lose weight also, with it's good fats. Ofcourse, it's not going to help if we eat half a jar all at once!!
Since I'm not a wine drinker, am specially keen on finding out this information.

Posted by HOFIII on 20 February 2008

Does decaf green tea have resveratrol in it? I'm under the impression that it does or is also very good for you. I drink approx. 4 to 5 cups daily in hopes that it does.

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