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A Wayne State University Health Clinic study has shown that a single pill containing both a blood pressure-lowering drug and a cholesterol-lowering drug may be of particular benefit for African Americans.
Researchers sponsored by Pfizer studied the effects of Pfizer's Caduet, a single pill that contains the drugs amlodipine and atorvastatin, used to lower high blood pressure and high cholesterol, respectively.
For as yet unestablished reasons, it is harder for African Americans than for the general U.S. population to bring blood pressure and "bad" LDL cholesterol under control. By providing a one-pill solution, researchers hoped to see a substantial improvement in control rates among African Americans.
They did. At the start of the study, which involved 499 African Americans with uncontrolled hypertension and elevated cholesterol or triglycerides, fewer than 1 percent had achieved control of those conditions. However, after receiving Caduet in eight different dosages, which were increased as needed, 48.3 percent of participants had achieved control over both conditions by week 20.
Patients tolerated the pill well. The most common treatment-related complications were peripheral swelling (3.4 percent), headache (2.2 percent), muscle pain (2.2 percent) and constipation (2.0 percent). Researchers say none of those reactions was considered severe.
Source: MedlinePlus; Mayo Clinic Proceedings
0 comments - Feb 20, 2008
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.