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A1c's Give Inaccurate Results for Hemodialysis Patients


Feb 27, 2008

A1c tests, the standard measurement of blood glucose, underestimate the amount of glucose in people who are on kidney hemodialysis, says a Wake Forest University Baptist Medical Center study.

The university tracked 307 diabetes patients, including 258 with end-stage kidney disease who routinely need dialysis to cleanse waste products in their blood. Researchers concluded that the tests consistently gave inaccurately low readings of blood glucose in those patients.

They indicated some surprise at the conclusion, both because of the possible damage to patients who have relied on A1c's to give them reliable indications of their blood glucose control, and because the test itself has always been considered a "gold standard."

Source: HealthDay


Categories: A1c Test, Blood Glucose, Diabetes, Diabetes, Kidney Care (Nephropathy)



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Comments

Posted by Barbarah on 28 February 2008

I wonder if the effects of a drug, given to impove effects of diabetes but which proved to be almost fatal,and resulted in the person having to have kidney dialysis, is sometimes reversible? Or is he considered to be in "end stage kidney failure?
I guess the real question is-once you are on dialysis,always on dialysis?

Posted by Anonymous on 5 March 2008

38 years as Type 1. Care for condition via Kidney/Pancreas transplant. Last A1c was 5.6. Was on peritoneal dialysis post initial Hemo- and until peritonel channel was stable.
Comment: After reading the article, I was about the amount of RBC's were actually destroyed during the actual hemo-dialysis. In the cell diffenention by life-span, was their a particular absence of older or younger cells. Maybe, the older RBC's were more subject to destruction and thus the undelying lower A1c. If no dialysis occured for several days, over the weekend, there may have been more RBC's still carrying sugar. Or, dialysis did NOT allow for the attachment of the glucose molecule to be attached to more of the specific carbon atom (the C-6?). Again, if the carbons are not there ro carry the glucose, or if they are there but the chemical adhesion is disrupted due to the mechanical process. vKn

Does that make sense?


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