Good News for Byetta (Exenatide): Canadian Study Reports Once-Weekly Dose Is Better at BG Control Than Twice Daily

An experimental long-term version, injected once weekly (versus the twice-daily routine in current use), provides better control of blood sugar and is better tolerated by users’ gastrointestinal systems.

Sep 11, 2008

A Canadian clinical study has delivered a double dose of good news for proponents of exenatide (sold commercially as Byetta), a drug used by more than 700,000 Americans to control blood glucose, ease food cravings, and, incidentally, lose weight.  

An experimental long-term version, injected once weekly (versus the twice-daily routine in current use), provides better control of blood sugar and is better tolerated by users' gastrointestinal systems.

Those are the conclusions of a study by Dr. Daniel Drucker and colleagues at the Mount Sinai Hospital and University of Toronto in Ontario, Canada. Dr. Drucker's study was presented at a recent meeting of the European Association for the Study of Diabetes in Rome, and will be published in the British medical journal The Lancet

The randomized trial followed 259 type 2 diabetes patients who had had diabetes an average of nearly seven years, tracking their A1c levels for 30 weeks. The mean A1c level for the group was 8.3% at the start of the study. 

One group of 129 patients received a once-weekly 2 mg (milligram) injection of exenatide. The other group of 130 patients received exenatide injections of 10µg (micrograms) twice daily. 

The patients on the once-weekly regimen saw their A1c levels fall to a mean of 6.4% (a -1.9% improvement), while those taking the drug twice daily saw their A1c's fall to 6.8% (a -1.5% improvement). 

More patients in the once-weekly group, 77 percent, achieved the study target of an A1c of 7.0% or less, compared with 61 percent of those in the twice-daily group. 

The percentages of those achieving A1c's of 6.5% or less were similar in both groups. The authors concluded, "Exenatide once weekly resulted in significantly greater improvements in glycemic control than exenatide given twice a day, with no increased risk of hypoglycemia and similar reductions in bodyweight." 

The study is available online.

Click Here To View Or Post Comments

Categories: A1c Test, Blood Glucose, Blood Sugar, Byetta, Diabetes, Diabetes, Food, Losing weight, Low Blood Sugar, Medications Research, Type 2 Issues

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12th Annual Product Reference Guide
  • Insulin Syringe Chart
  • Insulin Pen Needles Chart
  • Fast-Acting Glucose
  • Sharps Disposal
  • Blood Glucose Meters Chart
  • Insulin Pumps Chart
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (3)

You May Also Be Interested In...


Posted by Anonymous on 10 April 2009

I used byetta to treat my Type 2 diabetes for 11 months and did well for the first 10, then I began experiencing terrible nausea, after each injection. I also lost 30+ lbs which in turn helped decrease my BG. If I could take it once a week with the same results and no gastrointestinal side effects I would take it without doubt. I think it is a wonderful medication.

Posted by Anonymous on 21 April 2009

If your experiancing nausea try what I did. Inject in your butt! I also take when needed a walmart brand of a prilsec 150 (gold box)the walmart brand is right next to these in my store. Within 1/2 hour my nausea is gone with one of these. The injections in the butt are what I use mainly in the AM hours or when I first get up and eat my first meal, I work the graveyard shift.

Posted by Anonymous on 1 July 2009

If you are having nausea with Byetta, go buy some powdered ginger capsules at the local health food store or online and take 3 with each shot. Ginger is a natural antiemetic and also a bit of an anti-inflammatory. Works like a charm for me!

Add your comments about this article below. You can add comments as a registered user or anonymously. If you choose to post anonymously your comments will be sent to our moderator for approval before they appear on this page. If you choose to post as a registered user your comments will appear instantly.

When voicing your views via the comment feature, please respect the Diabetes Health community by refraining from comments that could be considered offensive to other people. Diabetes Health reserves the right to remove comments when necessary to maintain the cordial voice of the diabetes community.

For your privacy and protection, we ask that you do not include personal details such as address or telephone number in any comments posted.

Don't have your Diabetes Health Username? Register now and add your comments to all our content.

Have Your Say...

Username: Password:
©1991-2015 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.