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Researchers Suggest Adjusting the Glucose Level We Think of as Hypoglycemia
The researchers suggest that if hypoglycemia is to be defined by a predetermined glucose level, then the cut-off should be set at a lower level than the threshold of 3.9 mmol/l proposed by the ADA.
An article published in Diabetologia this month challenges the accepted glucose cut-off values that define hypoglycemia because they have a major effect on reported frequencies of hypoglycemia.
Researchers set out to quantify the relationship between the frequency of hypoglycemia and various glucose cut-off points for the definition of hypoglycemia, within a range of A1c strata.
Data from two trials examining insulin glargine dose titration in 12,837 type 2 participants with diabetes starting insulin therapy were combined. Curves for hypoglycemia frequency plotted against endpoint A1c level were constructed, using a range of glucose cut-off points for hypoglycemia.
During the 12-week study period, 3,912 patients recorded 21,592 hypoglycemic episodes, which were classified as either "severe," "symptomatic," or "asymptomatic" events.
The researchers concluded that the glucose cut-off point defining hypoglycemia greatly affects the reported frequency of hypoglycemia. In order to have clinical relevance, and if hypoglycemia is to be defined by a predetermined glucose level, then the cut-off should be set at a lower level than the threshold of 3.9 mmol/l proposed by the American Diabetes Association.
Categories: A1c Test, Blood Sugar, Diabetes, Diabetes, Hypoglycemia Unawareness, Insulin, Low Blood Sugar, Research, Type 2 Issues
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Sep 29, 2008
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Diabetes Health
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.
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Topics
- Diabetic / Diabetes Health
- Type 1 / 1.5 Diabetes
- Type 2 Diabetes
- Blood Glucose / Sugar
- High/Low Blood Sugar / Fast Acting Glucose
- Insulin- Pumps, Pens & Syringes
- Continuous Glucose Monitors, CGM, Infusion Sets
- Type 2 Medications
- Hyperglycemia
- Hypoglycemia
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