Sanofi-Aventis Study Sees Significant A1c Reductions with Lantus and Apidra Compared to Pre-mixed Insulin for Type 2s

This press release is an announcement submitted by Sanofi-aventis, and was not written by Diabetes Health.

The study showed that people with type 2 treated with Lantus and Apidra achieved significant reductions in their A1c compared to those treated with pre-mixed insulin.

Sep 29, 2008

At the recent 44th annual meeting of the European Association for the Study of Diabetes (EASD), sanofi-aventis announced a study demonstrating that a basal-bolus insulin regimen with Lantus® once daily (basal insulin) and rapid-acting Apidra® (insulin glulisine [rDNA origin] injection) at mealtime (bolus insulin) resulted in significant A1c reductions from baseline as compared to pre-mixed insulin in people with type 2 diabetes.

In the GINGER study, the overall A1c change from baseline to endpoint with Lantus and Apidra was 1.3% versus 0.8% with pre-mix.  The number of patients who reached an A1c of less than 7.0% at endpoint was significantly higher with Lantus and Apidra when compared to pre-mixed insulin.

Source: Sanofi-aventis

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Categories: A1c Test, Apidra, Diabetes, Diabetes, Insulin, Lantus, Type 2 Issues, Type 2 Medications

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Posted by wifey on 30 September 2008

Absolutely. My husband had been on this regime (with Lantus and Humalog) for three years before he died recently of bladder cancer, and kept very tight control with an excellent HgA1c of 6.1. As soon as he went into hospital, that ended because they insisted on sliding scale, which most certainly worked against him. I'd often test him when I visited him and he'd be far too high.
I presume that nurses in hospitals do not have enough time to take care of individual diabetic patients' needs.

Posted by fatfaria on 6 October 2008

Absolutely right! The combination of Lantus and Humalog is fundamental to a strict BG control program for my T1 diabetes. Consistent < 7 A1c's is the norm, now, as opposed to low 7's in the past.

Posted by Anonymous on 13 October 2008

I found this article to be "comical" to say the least. Like everyone doesn't already know that basal/bolus thearpy is the gold standard for tight glycemic control and not pre-mix. However some patients would rather take 2 shots a day versus 4/5. The other "comical" issue is that every person that commented talks about Humalog and not Apidra! Lilly invented insulin and Aprida is just another me-too product. Sanofi needs to stop wasting money on these uncessary studies. They also need to stop promoting Lantus as a "cure all" solution to type 2 diabetes and invest money into patient education to help patients understand basal/bolus thearpy NOT DOCTORS!

Posted by gramj on 21 November 2008

have just started to use the solo star pen and really like it but...the cost is horrible and can't aford it my dr. gave me a couple of samples but just a couple of 3 month prescriptions will put me in the "donut hole" at medicare ( need 12 pens per 3 months @ 40 units per day) any suggestions...may have to stick with the lantus vials...even that ain't cheap.

Posted by Anonymous on 27 November 2009

SoloStar is good but you may have to stick yourself twice when the remaining volume in the pen is less than what you need for the next injection. I prefer Lantus vial because there is very little waste.
I think SolaStar should contain at least 5 ml instead of 3 ml. Again, pen is so much more expensive than vial Lantus

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