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Non-Beta Pancreatic Cells Can Be Stimulated to Become New Beta Cells

Dec 2, 2008

The finding addresses two problems: finding a new source of beta cells with which to treat type 1 diabetes via transplantation, and overcoming recipients’ immune system reactions to transplanted cells.

Non-beta "progenitor" cells in the pancreas can be stimulated to turn into beta cells even after birth or autoimmune injury to the pancreas, say researchers at Joslin Diabetes Center in Boston, an affiliate of Harvard Medical School.

The cells, pancreatic duct cells, can be coaxed inside or outside the body to become insulin-producing beta cells. The finding addresses two problems: finding a new source of beta cells with which to treat type 1 diabetes via transplantation, and overcoming recipients' immune system reactions to transplanted cells.

If a person's own pancreatic progenitor cells could be transformed into beta cells, both problems would be solved. 

The Joslin study challenges the results of an earlier Harvard study, published in 2004, which concluded that after birth new beta cells could only result from division of preexisting beta cells. It also asserted that beta cells do not form from progenitor cells after birth. 

The study's immediate implication is that an unexpected new source of beta cells will be available for replacement therapy. Eventually, the research findings could be used in therapies designed to allow people with diabetes to regenerate their own islet cells


Categories: Diabetes, Diabetes, Insulin, Islet & Pancreas Transplant, New Cure Research, Type 1 Issues



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Comments

Posted by rosiolady on 3 December 2008

Ever since the first implant studies I've wondered, if destruction of the beta cells is caused by an autoimmune problem, what will prevent the new cells, however generated, from being destroyed in the same way? It's always seemed to me that the answer to type 1 would have to come with learning how to stop the autoimmune destruction process. But then, I'm not a medically trained person. When I asked this of my endocrinologist some years back, his answer was: Yes, that is a problem.

Posted by mahmoud on 20 January 2009

it good to go on this ways
plz tell me if i can treat myself from diapetis for ever
if i can plz contact me

Posted by Anonymous on 2 July 2013

So is anyone looking at furthering this research.


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