You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View
Latest Diabetes Articles
Popular Diabetes Articles
Highly Recommended Diabetes Articles
Send a link to this page to your friends and colleagues.
Researchers at the Washington University School of Medicine in St. Louis studied 15 type 1 patients (average A1c: 7.1%) to see if terbutaline could prevent hypoglycemic episodes during sleep without causing hyperglycemia the following morning.
(Terbutaline, which goes under the trade names Brethine, Bricanyl, and Brethaire, is typically used as a fast-acting bronchodilator in asthma patients. Doctors also use it to delay premature labor.)
Some patients were randomly assigned a dose of 2.5 mg of terbutaline each night before going to sleep. A second group received a 5 mg dose. A third group received a placebo. The patients received their respective doses at 10 p.m. on three separate nights.
The mean lowest plasma glucose concentrations at night among the groups were:
Morning plasma glucose levels were:
Although the mean figures for the 2.5 mg terbutaline group seem to be closer to the ideal, seven patients in the group reached a nadir nocturnal concentration of 70 mg/dl; six reached 60 mg/dl; and two reached 50 mg/dl in the course of the study. While three patients in the 5 mg group reached a nadir of 70 mg/dl, none in the group reached a lower level.
The researchers had previously reported on the effectiveness of a 5 mg dose of terbutaline, but were concerned that its morning plasma glucose levels were high. While the study tentatively established the effectiveness of the 2.5 mg dose, researchers have called for a much longer, more extensive trial of the drug among type 1s.
Dec 29, 2008
Diabetes Health is the essential resource for people living with diabetes- both newly diagnosed and experienced as well as the professionals who care for them. We provide balanced expert news and information on living healthfully with diabetes. Each issue includes cutting-edge editorial coverage of new products, research, treatment options, and meaningful lifestyle issues.