Marrow Cells Heal Neuropathy in Mice

If bone marrow cells could be cultured to work similarly in humans, it would be a significant step forward in the treatment of neuropathy, one of diabetes’ most dangerous effects.

Feb 12, 2009

Bone marrow cells that the body normally uses to restore blood vessels can be cultured to stop neuropathy and restore nerve function in diabetic mice, according to researchers at Emory University in Atlanta, Georgia.

If bone marrow cells could be cultured to work similarly in humans, it would be a significant step forward in the treatment of neuropathy, one of diabetes' most dangerous effects. In most people, high blood sugar eventually damages the blood vessels that supply peripheral nerves in the body, especially in the upper and lower limbs. In its most advanced form, neuropathy can lead to amputation.

In the Emory study, scientists worked on the assumption that bone marrow contains cells, called endothelial progenitors, which can divide into cells that are able to restore damaged blood vessels. They wanted to see if marrow cells especially enriched with endothelial progenitors could also be used to help regrow the nerve linings in diabetic mice. They injected the cells near the sciatic nerve in the test mice. (The sciatic is a large nerve in mammals that extends from the back to a rear leg.) Over the course of a few weeks, nerve signal speed and temperature sensitivity in the mice were restored to normal. 

The Emory team reported that the restoration of nerve function occurred despite the fact that only a fraction of the bone marrow cells actually became endothelial cells. The scientists also found that the cells appeared to "home" in on peripheral nerves-a characteristic that makes their eventual application in humans even more promising. 

Click Here To View Or Post Comments

Categories: Blood Sugar, Diabetes, Diabetes, Nerve Care (Neuropathy), Other Lab Tests, Professional Issues

Take the Diabetes Health Pump Survey
See What's Inside
Read this FREE issue now
For healthcare professionals only
  • 12th Annual Product Reference Guide
  • Insulin Syringe Chart
  • Insulin Pen Needles Chart
  • Fast-Acting Glucose
  • Sharps Disposal
  • Blood Glucose Meters Chart
  • Insulin Pumps Chart
See the entire table of contents here!

You can view the current or previous issues of Diabetes Health online, in their entirety, anytime you want.
Click Here To View

See if you qualify for our free healthcare professional magazines. Click here to start your application for Pre-Diabetes Health, Diabetes Health Pharmacist and Diabetes Health Professional.

Learn More About the Professional Subscription

Free Diabetes Health e-Newsletter

Top Rated
Print | Email | Share | Comments (12)

You May Also Be Interested In...

Click Here To View Or Post Comments

Comments 12 comments - Feb 12, 2009

©1991-2015 Diabetes Health | Home | Privacy | Press | Advertising | Help | Contact Us | Donate | Sitemap

Diabetes Health Medical Disclaimer

The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. All content, including text, graphics, images, and information, contained on or available through this website is for general information purposes only. Opinions expressed here are the opinions of writers, contributors, and commentators, and are not necessarily those of Diabetes Health. Never disregard professional medical advice or delay seeking medical treatment because of something you have read on or accessed through this website.